NADD+ and NADH

NADH for PD:

(NADH) has been used as medication in 885 PD patients in an open label trial. About half of the patients received NADH by intravenous infusion, the other part orally by capsules. In about 80% of the patients a beneficial clinical effect was observed

NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344

older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf

NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh

NR+?

Most sources say boost  NAD+ using precursors or NAD+ supplement (NMN, NR)

also oxaloacetate :

oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate

see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x

NAD+

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

NADH for PD:

short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…

liposomal NMN ?

all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)

Metformin 1 gr at night (checkout supplement alternative Berberine )

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily

make a list according to this guy

checkout Uleic vs resveratrol

Risk:

Metformin may increase risk of PD and other neurodegenerative disease

Keto for PD, Some Evidence

…What are the benefits of Ketosis?
Achieving a state of ketosis can have many benefits from treating chronic illnesses to optimizing performance. While the benefits are well documented, the underlying mechanism of action is not entirely known. The diet seems to enhance the ability of mitochondria, the power plants of our cells, to deliver our bodies’ energy needs in a manner that reduces inflammation and oxidative stress. Through optimizing the way our body uses energy, we fortify our bodies’ ability to take on the ever-growing stressors of our modern way of living.

some results:
charliefoundation.org/keto-for-parkinsons/

Vitamin D

does vit D cause calcification of arteries?
according to one article, it could in some settings, not clear when, many other sources point out the benefits of vit d

Vitamin D in Vascular Calcification: A Double-Edged Sword?

#q
How much sun exposure is needed for vit D instead of supplements?

answer from https://www.healthline.com/nutrition/vitamin-d-from-sun#time-of-day

At noon, the sun is at its highest point, and its UVB rays are most intense. That means you need less time in the sun to make sufficient vitamin D (5Trusted Source).

Many studies also show that the body is most efficient at making vitamin D at noon (6Trusted Source, 7Trusted Source).

For example, in the UK, 13 minutes of midday sunlight exposure during summer three times per week is enough to maintain healthy levels among Caucasian adults (5Trusted Source).

Another study found that 30 minutes ttof midday summer sun exposure in Oslo, Norway was equivalent to consuming 10,000–20,000 IU of vitamin D (8Trusted Source).

The commonly recommended daily dose of vitamin D is 600 IU (15 mcg) (3).

Vitamin D is critical for brain health…

Stem Cell – Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press

Current approaches to cell replacement therapy in Parkinson’s disease are strongly focused on the dopamine system, with the view that restoring dopaminergic inputs in a localized and physiologic manner will provide superior benefits in terms of effec

Source: Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press

נזקי כספית, אמלגם

ש לציין שהחריגות הגבוהות ביותר נמדדו בקידוח סתימות ישנות. יתרה מכן, בשנת 2002 פורסמה עבודה שבדקה 180 רופאי שיניים, ומצאה רמות כספית שעולה על הרמה המומלצת ע”י ה – Health and Safety Executive’s. חוקרים נוספים ערכו ניסוי קליני ובמהלכו הוסרו והוחלפו 50 סתימות אמלגם ישנות ותוך כדי כך נעשו מדידות של רמות אדי כספית באזור דרכי נשימה של רופאי שיניים. בחלק מהפעולות נמדדו רמות אדי כספית גבוהות מה TLV בין פי 2 עד פי 15

 

ארגון הבריאות העולמי וה 

FDA 

על אמלגם

 

High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson’s Disease – IOS Press

Background: Reduced glucose tolerance has been long recognized as a potential risk factor for Parkinson’s disease (PD), and increasing scrutiny is currently being placed on insulin resistance (IR) as a pathologic driver of neurodegeneration. However,

Source: High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson’s Disease – IOS Press

for comparison, prevalence of Diabetes in the general population:

Depending on age groups, global diabetes prevalence is about 5% for the age group 35-39 years, 10% for the age group 45-49 years, 15% for the age group 55-59 years, and close to 20% starting at age group 65-69 years. (1) Diabetes prevalence numbers are largely determined by people with type2 diabetes who comprise about 90% of the total population. These individuals are characterized by various degrees of relative insulin deficiency in conjunction with a wide spectrum of insulin resistance

its high – 20% suggesting much higher prevalence of IR, not sure if IR in PD is that much above normal

Whole body vibration: Neuro-rehab applications

www.ncbi.nlm.nih.gov/pmc/articles/PMC4100042/

buy:

www.aliexpress.com/item/2018-New-Exercise-Vibration-Fitness-Massager-for-Keeping-Health-Fitness-Equipment-Fitness-Body-Building-Workout-Equipments/32947451945.html?spm=2114.10010108.1000014.3.181f12d5FcO9LE&gps-id=pcDetailBottomMoreOtherSeller&scm=1007.13338.133244.0&scm_id=1007.13338.133244.0&scm-url=1007.13338.133244.0&pvid=3d910f33-3626-4deb-89cf-3c1b8a4ef79c