NADD+ and NADH
NADH for PD:
NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344
older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf
NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh
NR+?
Most sources say boost NAD+ using precursors or NAD+ supplement (NMN, NR)
also oxaloacetate :
see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x
NAD+
short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…
liposomal NMN ?
all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant
David Sinclair personal anti aging supplements protocol
NMN 1 gr with food(fat) in the morning, proven to raise NAD
Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)
Metformin 1 gr at night (checkout supplement alternative Berberine )
#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377
#q2: interaction with Warfarin
Avoid mamals due to TAMO
From 4:30 here:
another list,from fastlifehacks.com/david-sinclair-supplements/
David Sinclair Takes:
Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily
make a list according to this guy
checkout Uleic vs resveratrol
Risk:
Metformin may increase risk of PD and other neurodegenerative disease
Autophagy supplements
Spermadin
Resveratrol
EGCG (green tea)
Coffee
Olive oil
Coconut oil
MCT oil
Rishi mushroom
Burberberin
Solphorofen (Broccoli sprouts)
turmeric
ginger
Vitamin D
LP(a) lipoprotein(a)
Keto for PD, Some Evidence
…What are the benefits of Ketosis?
Achieving a state of ketosis can have many benefits from treating chronic illnesses to optimizing performance. While the benefits are well documented, the underlying mechanism of action is not entirely known. The diet seems to enhance the ability of mitochondria, the power plants of our cells, to deliver our bodies’ energy needs in a manner that reduces inflammation and oxidative stress. Through optimizing the way our body uses energy, we fortify our bodies’ ability to take on the ever-growing stressors of our modern way of living.
some results:
charliefoundation.org/keto-for-parkinsons/
stop and reverse PD, the state of the art
Vitamin D
does vit D cause calcification of arteries?
according to one article, it could in some settings, not clear when, many other sources point out the benefits of vit d
Vitamin D in Vascular Calcification: A Double-Edged Sword?
#q
How much sun exposure is needed for vit D instead of supplements?
answer from https://www.healthline.com/nutrition/vitamin-d-from-sun#time-of-day
At noon, the sun is at its highest point, and its UVB rays are most intense. That means you need less time in the sun to make sufficient vitamin D (5Trusted Source).
Many studies also show that the body is most efficient at making vitamin D at noon (6Trusted Source, 7Trusted Source).
For example, in the UK, 13 minutes of midday sunlight exposure during summer three times per week is enough to maintain healthy levels among Caucasian adults (5Trusted Source).
Another study found that 30 minutes ttof midday summer sun exposure in Oslo, Norway was equivalent to consuming 10,000–20,000 IU of vitamin D (8Trusted Source).
The commonly recommended daily dose of vitamin D is 600 IU (15 mcg) (3).
Vitamin D is critical for brain health…
Reductive stress – to much antioxidants
Chronic inflammation and insulin resistance interactions
Stop and reverse PD
Probiotics for PD
Do brain-training games really work?
New scientific evidence challenges the alleged cognitive benefits of brain-training games. Exercise and sleep may be better ways to boost cognition.
electrolytes including sodium, calcium, potassium, magnesium, and chloride negativly asssociated with Dyskinesia in PD
Stem Cell – Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press
Current approaches to cell replacement therapy in Parkinson’s disease are strongly focused on the dopamine system, with the view that restoring dopaminergic inputs in a localized and physiologic manner will provide superior benefits in terms of effec
Source: Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press
CBD – Cannabinoids in PD
נזקי כספית, אמלגם
על אמלגם
Diabetes protocol
High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson’s Disease – IOS Press
Background: Reduced glucose tolerance has been long recognized as a potential risk factor for Parkinson’s disease (PD), and increasing scrutiny is currently being placed on insulin resistance (IR) as a pathologic driver of neurodegeneration. However,
for comparison, prevalence of Diabetes in the general population:
its high – 20% suggesting much higher prevalence of IR, not sure if IR in PD is that much above normal