Dietary intervention in acne: mTORC1 signaling promoted by Western diet

..emerging whole network of exaggerated mTORC1 signaling mediated by Western diet. The most important task of preventive dermatology will be the reduction of mTORC1. All three major stimulatory pathways of mTORC1 activation have to be attenuated. Dietary intervention in acne should thus (1) decrease total energy, glucose and fat intake, (2) diminish insulin/IGF-1 signaling predominantly mediated by high dairy protein consumption, and (3) should limit the total leucine uptake predominantly provided by increased animal protein intake including meat and dairy proteins. This comprehensive dietary strategy can only be achieved by higher consumption of vegetables and fruit and reduction of animal-derived food. Indeed, diets enriched in vegetables and fruits, vegan diet as wells as Paleolithic diet (excluding sugar, hyperglycemic grains and dairy) have all been demonstrated to improve insulin sensitivity in type 2 diabetes, and metabolic syndrome and showed preventive effects in the development of Alzheimer disease.,, According to the recent Korean acne diet study, the frequency of vegetables and fish intake was significantly higher in the acne-free control group than in the acne group consuming more hyperglycemic carbohydrates, processed meat and dairy products. Paleolithic diet regimens come close to the goal of attenuated mTORC1 signaling but have to consider that unlimited total protein intake may overstimulate leucine-mediated mTORC1 activation. Vegetable-accentuated diets provide less mTORC1 activating signals and additionally contain natural plant-derived mTORC1-inhibitors like resveratrol, EGCG, curcumin, genestein, and indole-3-carbinol monomers, precursors of 3,3′-diindolylmethane.






Source: Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet