Common drugs that can interact with warfarin include:
Aspirin or aspirin-containing products
Acetaminophen (Tylenol, others) or acetaminophen-containing products
Antacids or laxatives
Antifungal medications, such as fluconazole (Diflucan)
Cold or allergy medicines
Ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, Naprelan, others)
Medications that treat abnormal heart rhythms, such as amiodarone (Pacerone, Nexterone)
scan for more information on drug interaction:
Common supplements that can interact with warfarin include:
Vitamin K2 
Vitamin C 
Resveratrol (possibly safe, see )
Coenzyme Q10 (ubiquinone)
St. John’s wort
Flavonoids – safe 
Vitamin D3 – reduce vitamin K
Common foods and drinks that might interact with warfarin include:
Food high in Vitamin K (green leafy vegetables)*
Cranberries or cranberry juice
It’s important to have a consistent amount of vitamin K in your diet (if on warfarin). If you have little vitamin K in your diet, a sudden spike can increase your risk of bleeding.
Resistance to oral anticoagulants has been associated with high vit K food intake.
Foods rich in vitamin K include:
beef liver, broccoli, Brussels sprouts, cabbage, collard greens, endive, kale, lettuce, mustard greens, parsley, soy beans, spinach, Swiss chard, turnip greens, watercress, and other green leafy vegetables.
Moderate to high levels of vitamin K: asparagus, avocados, dill pickles, green peas, green tea, canola oil, margarine, mayonnaise, olive oil, and soybean oil. Snack foods containing the fat substitute,
olestra, are fortified with 80 mcg of vitamin K per each one ounce serving
Consumption of large amounts of mango fruit has been associated with enhanced effects of warfarin. The exact mechanism of interaction is unknown but may be related to the vitamin A content, which may inhibit metabolism of warfarin.
Limited data also suggest a potential interaction between warfarin and cranberry juice resulting in changes in the INR and/or bleeding complications.
There have been several case reports in the medical literature of patients consuming grapefruit, grapefruit juice, or grapefruit seed extract who experienced increases in INR. R(+) warfarin…possibly safe
.. elevated INR due to pomegranate juice
Black currant juice and black currant seed oil may theoretically increase the risk of bleeding or bruising if used in combination with anticoagulants.
Soy protein in the form of soy milk was thought to be responsible for a case of possible warfarin antagonism in an elderly male stabilized on warfarin. The exact mechanism of interaction is unknown, as soy milk contains only trace amounts of vitamin K. Subtherapeutic INR values were observed approximately 4 weeks after the patient began consuming soy milk daily for the treatment of hypertriglyceridemia. No other changes in diet or medications were noted during this time. The patient’s INR returned to normal following discontinuation of the soy milk with no other intervention.
An interaction with chewing tobacco was suspected in a case of warfarin therapy failure in a young male who was treated with up to 25 to 30 mg/day for 4.5 years. The inability to achieve adequate INR values led to eventual discontinuation of the chewing tobacco, which resulted in an INR increase from 1.1 to 2.3 in six days. The authors attributed the interaction to the relatively high vitamin K content in smokeless tobacco.
Some experts recommend that continuous enteral nutrition should be interrupted for one hour before and one hour after administration of the anticoagulant dose and that enteral formulas containing soy protein should be avoided. Anticouglant users should consider limiting the consumption of cranberry juice or other cranberry formulas or pomegranate juice, black currant juice, and black currant seed oil.
<h2) Natural blood thinners</H2
Celery, galic, vit C
are does Warferin alternativesss,
need some postapocaliptiiic solution, assumin, only
Other blood thinning medication:
Plavix – avoid grapefruits, Celery
לתרופות החדשות למניעת קרישה (קסרלטו, אליקוויס ופרדקסה) כמעט שאין התנגשויות ידועות עם מזון.
avoid grapefruits, Celery, garlic
לבני ממליצה גם להיזהר ממזונות מדללי דם כמו סלרי ושום ולא לצרוך אותם בכמויות גדולות, למרות שכרגע אין מידע על אינטראקציות של מזונות אלה עם התרופות החדשות.
 Vitamin C
Vitamin C with Rose Hips (ascorbic acid)
Ascorbic acid has been implicated in causing warfarin resistance. However, controlled clinical trials have not demonstrated clinically important variations in prothrombin times. The possibility of an interaction may be considered if warfarin resistance is encountered in patients taking high doses of ascorbic acid.
Smith EC, Skalski RJ, Johnson GC, Rossi GV “Interaction of ascorbic acid and warfarin.” JAMA 221 (1972): 1166
Hume R, Johnstone JM, Weyers E “Interaction of ascorbic acid and warfarin.” JAMA 219 (1972): 1479
Rosenthal G “Interaction of ascorbic acid and warfarin.” JAMA 215 (1971): 1671
Weintraub M, Griner PF “Warfarin and ascorbic acid: lack of evidence for a drug interaction.” Toxicol Appl Pharmacol 28 (1974): 53-6
Feetam CL, Leach RH, Meynell MJ “Lack of a clinically important interaction between warfarin and ascorbic acid.” Toxicol Appl Pharmacol 31 (1975): 544-7
 = flavonoids, no interaction with Warfarin – www.ncbi.nlm.nih.gov/pubmed/28696372qqqq
Guo LQ, Yamazoe Y “Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines.” Acta Pharmacol Sin 25 (2004): 129-36
Bodiford AB, Kessler FO, Fermo JD, Ragucci KR “Elevated international normalized ratio with the consumption of grapefruit and use of warfarin.” SAGE Open Med Case Rep 0 (2013): 1-3
Suvarna R, Pirmohamed M, Henderson L “Possible interaction between warfarin and cranberry juice.” BMJ 327 (2003): 1454
Beckey NP, Korman LB, Parra D “Effect of the moderate consumption of olestra in patients receiving long-term warfarin therapy.” Pharmacotherapy 19 (1999): 1075-9
Kempin SJ “Warfarin resistance caused by broccoli.” N Engl J Med 308 (1983): 1229-30
Sullivan DM, Ford MA, Boyden TW “Grapefruit juice and the response to warfarin.” Am J Health Syst Pharm 55 (1998): 1581-3
Westfall LK “An unrecognized cause of warfarin resistance.” Drug Intell Clin Pharm 15 (1981): 131
Harrell CC, Kline SS “Vitamin K-supplemented snacks containing olestra: Implication for patients taking warfarin.” Jama J Am Med Assn 282 (1999): 1133-4
Walker FB “Myocardial infarction after diet-induced warfarin resistance.” Arch Intern Med 144 (1984): 2089-90
Pedersen FM, Hamberg O, Hess K, Ovesen L “The effect of dietary vitamin K on warfarin-induced anticoagulation.” J Intern Med 229 (1991): 517-20
Grant P “Warfarin and cranberry juice: an interaction?” J Heart Valve Dis 13 (2004): 25-6
Griffith LD, Olvey SE, Triplett WC “Increasing prothrombin times in a warfarin-treated patient upon withdrawal of ensure plus.” Crit Care Med 10 (1982): 799-800
Ge B, Zhang Z, Zuo Z “Updates on the clinical evidenced herb-warfarin interactions.” Evid Based Complement Alternat Med 2014 (2014): 957362
Kazmier FJ, Spittell JA Jr “Coumarin drug interactions.” Mayo Clin Proc 45 (1970): 249-55
Wells PS, Holbrook AM, Crowther NR, Hirsh J “Interactions of warfarin with drugs and food.” Ann Intern Med 121 (1994): 676-83
Agencia Española de Medicamentos y Productos Sanitarios Healthcare “Centro de información online de medicamentos de la AEMPS – CIMA. Available from: URL: cima.aemps.es/cima/publico/home.html.” ():
Zallman JA, Lee DP, Jeffrey PL “Liquid nutrition as a cause of warfarin resistance.” Am J Hosp Pharm 38 (1981): 1174
Watson AJ, Pegg M, Green JR “Enteral feeds may antagonise warfarin.” Br Med J 288 (1984): 557
Monterrey-Rodriguez J “Interaction between warfarin and mango fruit.” Ann Pharmacother 36 (2002): 940-1
Roberts D, Flanagan P “Case report: Cranberry juice and warfarin.” Home Healthc Nurse 29 (2011): 92-7
Griffiths AP, Beddall A, Pegler S “Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin.” J R Soc Health 128 (2008): 324-6
Parr MD, Record KE, Griffith GL, et al “Effect of enteral nutrition on warfarin therapy.” Clin Pharm 1 (1982): 274-6
Chow WH, Chow TC, Tse TM, Tai YT, Lee WT “Anticoagulation instability with life-threatening complication after dietary modification.” Postgrad Med J 66 (1990): 855-7
Hamann GL, Campbell JD, George CM “Warfarin-cranberry juice interaction.” Ann Pharmacother 45 (2011): e17
Andersen P, Godal HC “Predictable reduction in anticoagulant activity of warfarin by small amounts of vitamin K.” Acta Med Scand 198 (1975): 269-70
Howard PA, Hannaman KN “Warfarin resistance linked to enteral nutrition products.” J Am Diet Assoc 85 (1985): 713-5
MacLeod SM, Sellers EM “Pharmacodynamic and pharmacokinetic drug interactions with coumarin anticoagulants.” Drugs 11 (1976): 461-70
Rindone JP, Murphy TW “Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding.” Am J Ther 13 (2006): 283-4
Jarvis S, Li C, Bogle RG “Possible interaction between pomegranate juice and warfarin.” Emerg Med J 27 (2010): 74-5
Lee M, Schwartz RN, Sharifi R “Warfarin resistance and vitamin K.” Ann Intern Med 94 (1981): 140-1
Brandin H, Myrberg O, Rundlof T, Arvidsson AK, Brenning G “Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy.” Eur J Clin Pharmacol 63 (2007): 565-70
Kuykendall JR, Houle MD, Rhodes RS “Possible warfarin failure due to interaction with smokeless tobacco.” Ann Pharmacother 38 (2004): 595-7
Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT “Recommendations for the use of medications with continuous enteral nutrition.” Am J Health Syst Pharm 66 (2009): 1438-67
MHRA. Mediciines and Healthcare products Regulatory Agency. Committee on Safety of Medicines “Possible interaction between warfarin and cranberry juice. Available from: URL: medicines.mhra.gov.uk/ourwork/monitorsafequalmed/currentproblems/currentproblems.htm.” ([2003 Sept]):
Karlson B, Leijd B, Hellstrom K “On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment.” Acta Med Scand 220 (1986): 347-50
O’Reilly RA, Rytand DA “”Resistance” to warfarin due to unrecognized vitamin K supplementation.” N Engl J Med 303 (1980): 160-1
Cambria-Kiely JA “Effect of soy milk on warfarin efficacy.” Ann Pharmacother 36 (2002): 1893-6