Source: Drug-Induced Parkinsonism
Action items that may improve PD status
- evidence-based
- Root causes may play a role in many conditions, in all causes listed below, a link to PD was found
- Key items in the list include: Keto, Fasting, Intermittent fasting, FMD, mitochondria support, micronutrient optimization/supplementation, macro’s, pathogens, poisons, mind-body, motor learning, masticking, vibration therapy, diet, exercise, EMF radiation dysbiosis & licky gut. cold/ heat exposure, hormetic stressors, sleep optimization.
- The goal of the list is to map causes and available treatments relevant to the condition.
- This is a work in progress, adding new items all the time (sign up for updates)
- Visit https://healthlinks.cc/list/meds/pd-meds/ for the meds related
Probiotics for PD
New treatments for PD, in trials
direct administration to the brain (that’s new) of GDNF (also new)
The FDA granted approval of Nourianz to Kyowa Kirin, Inc.
- A universal feature of Parkinson’s is aggregation, or clumping, of the protein alpha-synuclein in the brains and body cells of people with the disease (similar to the amyloid clumps seen in Alzheimer’s disease). Multiple drug companies are conducting clinical trials to try to prevent or break up synuclein clumps, which scientists believe could stop PD in its tracks.
- Several potentially disease-modifying therapies continue to advance via “repurposing” — scientifically evaluating drugs approved for various conditions for their benefit in PD. Isradipine (a hypertension drug) and inosine (an antioxidant supplement) are now in Phase III trials. The field also has seen promise in the diabetes drug exenatide and the cancer drug nilotinib.
3 day fast-rebuild immune system, Longo
good for chronic autoimmune conditions
www.cell.com/cell/fulltext/S0092-8674(19)30852-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419308529%3Fshowall%3Dtrue
IP6 Chealator
NADD+ and NADH
NADH for PD:
NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344
older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf
NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh
NR+?
Most sources say boost NAD+ using precursors or NAD+ supplement (NMN, NR)
also oxaloacetate :
see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x
NAD+
short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…
liposomal NMN ?
all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant
Autophagy supplements
Spermadin
Resveratrol
EGCG (green tea)
Coffee
Olive oil
Coconut oil
MCT oil
Rishi mushroom
Burberberin
Solphorofen (Broccoli sprouts)
turmeric
ginger
Vitamin D
LP(a) lipoprotein(a)
Keto for PD, Some Evidence
…What are the benefits of Ketosis?
Achieving a state of ketosis can have many benefits from treating chronic illnesses to optimizing performance. While the benefits are well documented, the underlying mechanism of action is not entirely known. The diet seems to enhance the ability of mitochondria, the power plants of our cells, to deliver our bodies’ energy needs in a manner that reduces inflammation and oxidative stress. Through optimizing the way our body uses energy, we fortify our bodies’ ability to take on the ever-growing stressors of our modern way of living.
some results:
charliefoundation.org/keto-for-parkinsons/
stop and reverse PD, the state of the art
Vitamin D
does vit D cause calcification of arteries?
according to one article, it could in some settings, not clear when, many other sources point out the benefits of vit d
Vitamin D in Vascular Calcification: A Double-Edged Sword?
#q
How much sun exposure is needed for vit D instead of supplements?
answer from https://www.healthline.com/nutrition/vitamin-d-from-sun#time-of-day
At noon, the sun is at its highest point, and its UVB rays are most intense. That means you need less time in the sun to make sufficient vitamin D (5Trusted Source).
Many studies also show that the body is most efficient at making vitamin D at noon (6Trusted Source, 7Trusted Source).
For example, in the UK, 13 minutes of midday sunlight exposure during summer three times per week is enough to maintain healthy levels among Caucasian adults (5Trusted Source).
Another study found that 30 minutes ttof midday summer sun exposure in Oslo, Norway was equivalent to consuming 10,000–20,000 IU of vitamin D (8Trusted Source).
The commonly recommended daily dose of vitamin D is 600 IU (15 mcg) (3).
Vitamin D is critical for brain health…
Reductive stress – to much antioxidants
Stop and reverse PD
Probiotics for PD
Do brain-training games really work?
New scientific evidence challenges the alleged cognitive benefits of brain-training games. Exercise and sleep may be better ways to boost cognition.
electrolytes including sodium, calcium, potassium, magnesium, and chloride negativly asssociated with Dyskinesia in PD
Stem Cell – Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press
Current approaches to cell replacement therapy in Parkinson’s disease are strongly focused on the dopamine system, with the view that restoring dopaminergic inputs in a localized and physiologic manner will provide superior benefits in terms of effec
Source: Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies – IOS Press
CBD – Cannabinoids in PD
Fetal tissue implant – Wikipedia
Source: Fetal tissue implant – Wikipedia
…In 1982, seven people in Santa Clara County, California were diagnosed with Parkinsonism after having used MPPP contaminated with MPTP. In 1992, two of the seven patients were successfully treated at Lund University Hospital in Sweden with neural grafts of fetal tissue. One patient, who had been essentially paralyzed, regained enough motor function to ride a bicycle.[1]