For Indians, it appears that it would be most prudent to have a diet with about 50 per cent carbohydrate (using complex carbs and whole grains such as brown rice or whole wheat) about 20-25 per cent protein (preferably from vegetable proteins such as legumes and pulses) and the remaining 25-30 per cent from healthy fats like monounsaturated fats (e.g. groundnut oil or mustard oil and nuts and seeds) along with plenty of green leafy vegetables. Such a diet may not immediately give dramatic results as far as weight reduction is concerned. However, it will be sustainable in the long term and will be less risky and certainly more healthy and also help prevent non-communicable diseases such as diabetes, cardiovascular disease and certain cancers.
elevation of lymph ketone body levels by a high-fat, low-carbohydrate ketogenic diet or by administration of the ketone body β-hydroxybutyrate increases lymphangiogenesis – www.nature.com/articles/s42255-019-0087-y
Many studies show that low-carb and ketogenic diets can lead to dramatic weight loss and improve most major risk factors for heart disease and diabetes. Also, repeatedly shown (but not always) to help with or reverse PD and other neurologicsal conditions
some evidence exists regarding a potential protective effect of uric acid, poly-unsaturated fatty acids, coffee, and tea but mainly in men, whereas dairy products, particularly milk, might increase PD risk through contaminant mediated effect
Low carb diets (LCDs starting at a young age are associated with an increased risk of subsequent coronary artery calcification (CAC) progression, particularly when animal protein or fat are chosen to replace carbohydrates.
Guy: At this time I could find very few cases of trying carnivore for PD, actually none doing 100% carnivore.
According to Ronda Patrick below, Carnivore naturally includes caloric restriction, intermittent fasting, changes to the microbiome, low carb diet, and consuming more cholesterol those are 5 powerful tools which do not require a long term carnivore diet, which is a risk.
The one tool unique to a carnivore is eliminating all!! lectins (toxic molecules found in plants.
How significant is that in relation to the other tools and the diet outcome is yet to see.
another player to consider is MTOR high protein diet might shift it towards activation instead of deactivation
so, waiting for this to clear
In the following video, Dr. Ronda Patrick talks to Joe Rogan about the anecdotal evidence that suggests a carnivorous diet may be effective in alleviating the symptoms of autoimmune disorder, PD and other neurological conditions. She talks about her extensive 30-page work covering the trend towards a restrictive animal only diet. She discusses why someone would try this diet and how many immune disorder sufferers are trying low-carb high-protein diets because of the anecdotal reports they have heard.
Dr. Patrick talks about various studies related to high-protein diets and studies related to resetting your immune system through diet. This fascinating podcast brings up the anecdotal evidence and studies of various diets and their effect on autoimmune disorders and PD neurological conditions. She also discusses the effect of fasting, the potential damage of various diets, the modified Ketogenic diet, and the mechanisms that happen in the body when you restrict your diet or fast.
Michael E. McEvoy the founder of Metabolic Healing gives a summary of studies on the connection between cholesterol, Parkinson’s Disease, and statins. Cholesterol plays an important role in PD, yet it is very controversial for different reasons. A 2018 cohort study found higher total cholesterol and LDL was associated with a decreased risk of PD over time for men, but not for women. The 2008 Honolulu-Asia Aging study found PD incidence increased with decreasing LDL-C levels in a dose-dependent manner for men aged 71-75. A 2006 Rotterdam-based study found higher total cholesterol associated with a significantly decreased risk of PD in women only. A 2017 study of 2,322 PD patients found high cholesterol associated with lower PD risk. These studies establish that higher cholesterol is associated with lower PD risk.
Studies that have found statins were protective have been criticized for having significant population bias. As yet no study which has shown statin protection against PD has accounted for patients with hyperlipidemia (these studies have excluded patients with hyperlipidemia). A 2017 study investigating the possibility of statins used in association with PD suggested that statin use may facilitate the onset of pre-clinical PD.
Mike Mutzel from High Intensity Health (author of Belly Fat Effect) talks to Frank Llosa of KetoneAid. KetoneAid produces a Ketone Ester (raw beta-hydroxybutyrate (BHB) ketone) supplement that can get you into a deep state of ketosis within 30 minutes. You would have to fast or go on an intense ketogenic diet to reach the same ketosis state. There are different types of Keto testing, blood glucose testing, and different types of exogenous Ketones. Ketosis is influenced by BHB salts; Ketone supplements. There have been many discussions about the link between PD and the ketogenic diet. In one study PD patients were put on a ketogenic diet for a month and the results showed a 43% improvement in the Unified Parkinson’s Disease rating scale. There is no doubt that PD is affected by diet and nutrition so the ketogenic diet may offer relief from some symptoms.
Mike Mutzel from High-Intensity Health (author of Belly Fat Effect) talks to William Curtis about his PD journey and how a ketogenic diet changed his life. Curtis suffered from PD for over 17 years before he started exercising, fasting, and following a low-carb, ketogenic diet that remarkably improved his PD symptoms. Through trial and error, Curtis found the right balance in his diet. The William Curtis’ program for easing PD symptoms is not appropriate for everyone. For example, PD patients that have balance problems could do more harm to themselves if they followed Curtis’ diet. After 12 hours of fasting through the night, Curtis has a bulletproof coffee in the morning prepared with butter, heavy cream, coconut oil, and Stevia. This helps his PD symptoms and increases the ketone D-betahydroxybutyrate (BHB).
This 2019 report in the National Library of Medicine (National Center for Biotechnology Information) looks at lifestyles and dietary habits associated with PD. A fasting mimicking diet (FMD), fasting 3 days followed by 4 days of refeeding for three 1-week cycles, which accelerated the retention of motor function and attenuated the loss of dopaminergic neurons in the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mice. Levels of brain-derived neurotrophic factor (BDNF), known to promote the survival of dopaminergic neurons, were increased in PD mice after FMD, suggesting the involvement of BDNF in FMD-mediated neuroprotection. The findings showed that FMD also inhibited neuroinflammation and modulated the shifts in gut microbiota composition.
A research article published in Plos One in2018 looks at results of multiple observational studies focused on one or more cardio-metabolic risk factors in vegans and omnivorous diets. Macro-nutrient intake and cardio-metabolic risk factors were compared by dietary pattern. People on vegan diets and others on omnivorous diets were compared for energy, saturated fats, body mass index, lipoprotein cholesterol, triglycerides, glucose levels, blood pressure. The results support the idea that plant-based diets are likely to lower the risk of cardiovascular disease and diabetes.
In a 2019 systematic review article published on Frontiers in Nutrition, the link between vegetarian dietary patterns and various cardiovascular outcomes were examined. The aim was to update the European Association for the Study of Diabetes (EASD) clinical practice guidelines for nutrition therapy. Several prospective cohort studies were examined and the results considered. Although overall evidence was graded as “very low quality” there were indications that vegetarian dietary patterns are associated with reductions in CHD mortality and incidence but not with CVD and stroke mortality in individuals with and without diabetes.
A systematic literature review published on NCBI in July 2020 summarizes evidence from various publications in regard to the role of diet and nutrition as a cause of migraines and as migraine triggers. Data was gathered from primary literature sources from March 2019 to January 2000 in patients over 18 years old. A total of 43 studies were included in the review assessing diet patterns, diet interventions, and diet-related triggers. Among the diets assessed were low-fat, elimination diets, keto diet, and diet-related triggers such as alcohol and caffeine. The review concluded that there is limited high-quality randomized controlled trial data on diet patterns or diet-related triggers. Although many patients already reported avoiding personal diet-related triggers in their migraine management, further research is necessary.
An article published in the MDPI journal, Nutrients in June 2020 looks at the influence of dietary patterns and dietary triggers on migraines. Identifying these triggers is challenging because so many other factors such as age, genetics, sex, and individual immunological responses to food can influence migraines. If the triggers can be identified they can be avoided to prevent migraines. This review presents the current status of research into diet and migraines and how lifestyle changes may increase the quality of life of patients. The review examines elimination diets; migraine diets; epigenetic diets; the gut-brain axis and probiotics in relation to migraines. The review concludes that the selection of an appropriate diet and obtaining correct dietary counseling is recommended to ensure the biopsychosocial well-being of migraine patients, as strict food avoidance may result in stress and poor quality of life.
In this Goop podcast chief content officer at Goop, Elise Loehnen talks to Valter Longo, author of the longevity diet, as part of a series on detox, nutrition, and resetting the body. Longo is also one of the world’s leading experts on fasting. During the interview, they tackle questions such as “Is intermittent fasting the key to health?” Longo proposes fasting as one of the elements that contribute to longevity and to a healthy life, avoiding the diseases that often plague the elderly. The podcast also addresses the research surrounding the connection between fasting and preventing autoimmune diseases and cancer as well as the idea of making fasting part of standard cancer treatment. Longo discusses clinical trials including seven clinical trials supporting FMD (Fasting Mimicking Diet).
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