Ketogenic therapies for lymphedema

elevation of lymph ketone body levels by a high-fat, low-carbohydrate ketogenic diet or by administration of the ketone body β-hydroxybutyrate increases lymphangiogenesis –

from the lab –



10 Health Benefits of Low-Carb and Ketogenic Diets

Many studies show that low-carb and ketogenic diets can lead to dramatic weight loss and improve most major risk factors for heart disease and diabetes. Also, repeatedly shown (but not always) to help with or reverse PD and other neurologicsal conditions


Source: 10 Health Benefits of Low-Carb an

Low-Carbohydrate Diet, animal based, cause an increased risk for coronary artery calcification

Low carb diets (LCDs starting at a young age are associated with an increased risk of subsequent coronary artery calcification (CAC) progression, particularly when animal protein or fat are chosen to replace carbohydrates.

Could a Carnivore Diet Help with Autoimmune Disorders e.g PD

Guy: At this time I could find very few cases of trying carnivore for PD, actually none doing 100% carnivore.

According to Ronda Patrick below, Carnivore naturally includes caloric restriction, intermittent fasting, changes to the microbiome, low carb diet, and consuming more cholesterol those are 5 powerful tools which do not require a long term carnivore diet, which is a risk.

The one tool unique to a carnivore is eliminating all!! lectins (toxic molecules found in plants.

How significant is that in relation to the other tools and the diet outcome is yet to see.

another player to consider is MTOR high protein diet might shift it towards activation instead of deactivation

so, waiting for this to clear

P.M. :

In the following video, Dr. Ronda Patrick talks to Joe Rogan about the anecdotal evidence that suggests a carnivorous diet may be effective in alleviating the symptoms of autoimmune disorder, PD and other neurological conditions. She talks about her extensive 30-page work covering the trend towards a restrictive animal only diet. She discusses why someone would try this diet and how many immune disorder sufferers are trying low-carb high-protein diets because of the anecdotal reports they have heard.

Dr. Patrick talks about various studies related to high-protein diets and studies related to resetting your immune system through diet. This fascinating podcast brings up the anecdotal evidence and studies of various diets and their effect on autoimmune disorders and PD neurological conditions. She also discusses the effect of fasting, the potential damage of various diets, the modified Ketogenic diet, and the mechanisms that happen in the body when you restrict your diet or fast.

Cholesterol Provides Some Protection Against PD 

Michael E. McEvoy the founder of Metabolic Healing gives a summary of studies on the connection between cholesterol, Parkinson’s Disease, and statins. Cholesterol plays an important role in PD, yet it is very controversial for different reasons. A 2018 cohort study found higher total cholesterol and LDL was associated with a decreased risk of PD over time for men, but not for women. The 2008 Honolulu-Asia Aging study found PD incidence increased with decreasing LDL-C levels in a dose-dependent manner for men aged 71-75. A 2006 Rotterdam-based study found higher total cholesterol associated with a significantly decreased risk of PD in women only. A 2017 study of 2,322 PD patients found high cholesterol associated with lower PD risk. These studies establish that higher cholesterol is associated with lower PD risk.

Studies that have found statins were protective have been criticized for having significant population bias. As yet no study which has shown statin protection against PD has accounted for patients with hyperlipidemia (these studies have excluded patients with hyperlipidemia). A 2017 study investigating the possibility of statins used in association with PD suggested that statin use may facilitate the onset of pre-clinical PD.

Parkinson’s Pilot Program

Related research presented in the video

Types of Keto Testing, Blood Glucose Testing, and Types of Exogenous Ketones

Mike Mutzel from High Intensity Health (author of Belly Fat Effect) talks to Frank Llosa of KetoneAid. KetoneAid produces a Ketone Ester (raw beta-hydroxybutyrate (BHB) ketone) supplement that can get you into a deep state of ketosis within 30 minutes. You would have to fast or go on an intense ketogenic diet to reach the same ketosis state. There are different types of Keto testing, blood glucose testing, and different types of exogenous Ketones. Ketosis is influenced by BHB salts; Ketone supplements. There have been many discussions about the link between PD and the ketogenic diet. In one study PD patients were put on a ketogenic diet for a month and the results showed a 43% improvement in the Unified Parkinson’s Disease rating scale. There is no doubt that PD is affected by diet and nutrition so the ketogenic diet may offer relief from some symptoms.

Keto for PD: The William Curtis Story

Mike Mutzel from High-Intensity Health (author of Belly Fat Effect) talks to William Curtis about his PD journey and how a ketogenic diet changed his life. Curtis suffered from PD for over 17 years before he started exercising, fasting, and following a low-carb, ketogenic diet that remarkably improved his PD symptoms. Through trial and error, Curtis found the right balance in his diet. The William Curtis’ program for easing PD symptoms is not appropriate for everyone. For example, PD patients that have balance problems could do more harm to themselves if they followed Curtis’ diet. After 12 hours of fasting through the night, Curtis has a bulletproof coffee in the morning prepared with butter, heavy cream, coconut oil, and Stevia. This helps his PD symptoms and increases the ketone D-betahydroxybutyrate (BHB).

good results in rats

keto vs low fat
8 weeks
both diets had good results, keto was better

some ways Keto help are not well understood

Curtis has a website

Could Fasting Help Control PD Symptoms?

This 2019 report in the National Library of Medicine (National Center for Biotechnology Information) looks at lifestyles and dietary habits associated with PD. A fasting mimicking diet (FMD), fasting 3 days followed by 4 days of refeeding for three 1-week cycles, which accelerated the retention of motor function and attenuated the loss of dopaminergic neurons in the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mice. Levels of brain-derived neurotrophic factor (BDNF), known to promote the survival of dopaminergic neurons, were increased in PD mice after FMD, suggesting the involvement of BDNF in FMD-mediated neuroprotection. The findings showed that FMD also inhibited neuroinflammation and modulated the shifts in gut microbiota composition.

Source: Neuroprotection of Fasting Mimicking Diet on MPTP-Induced Parkinson’s Disease Mice via Gut Microbiota and Metabolites – PubMed

Can Plant-Based Diets Lower the Risk of Cardiovascular Disease?

A research article published in Plos One in2018 looks at results of multiple observational studies focused on one or more cardio-metabolic risk factors in vegans and omnivorous diets. Macro-nutrient intake and cardio-metabolic risk factors were compared by dietary pattern. People on vegan diets and others on omnivorous diets were compared for energy, saturated fats, body mass index, lipoprotein cholesterol, triglycerides, glucose levels, blood pressure. The results support the idea that plant-based diets are likely to lower the risk of cardiovascular disease and diabetes.

Source: Cardiometabolic Risk Factors in Vegans; a meta-analysis of observational studies

What Does a Vegetarian Diet Mean for Cardiovascular Health?

In a 2019 systematic review article published on Frontiers in Nutrition, the link between vegetarian dietary patterns and various cardiovascular outcomes were examined. The aim was to update the European Association for the Study of Diabetes (EASD) clinical practice guidelines for nutrition therapy. Several prospective cohort studies were examined and the results considered. Although overall evidence was graded as “very low quality” there were indications that vegetarian dietary patterns are associated with reductions in CHD mortality and incidence but not with CVD and stroke mortality in individuals with and without diabetes.

Souce: Relation of Vegetarian Dietary Patterns With Major Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies


Diet and Nutrition as Migraine Triggers

A systematic literature review published on NCBI in July 2020 summarizes evidence from various publications in regard to the role of diet and nutrition as a cause of migraines and as migraine triggers. Data was gathered from primary literature sources from March 2019 to January 2000 in patients over 18 years old. A total of 43 studies were included in the review assessing diet patterns, diet interventions, and diet-related triggers. Among the diets assessed were low-fat, elimination diets, keto diet, and diet-related triggers such as alcohol and caffeine. The review concluded that there is limited high-quality randomized controlled trial data on diet patterns or diet-related triggers. Although many patients already reported avoiding personal diet-related triggers in their migraine management, further research is necessary.

Source: The Role of Diet and Nutrition in Migraine Triggers and Treatments; a systematic literature review

The Migraine-Diet Connection

An article published in the MDPI journal, Nutrients in June 2020 looks at the influence of dietary patterns and dietary triggers on migraines. Identifying these triggers is challenging because so many other factors such as age, genetics, sex, and individual immunological responses to food can influence migraines. If the triggers can be identified they can be avoided to prevent migraines. This review presents the current status of research into diet and migraines and how lifestyle changes may increase the quality of life of patients. The review examines elimination diets; migraine diets; epigenetic diets; the gut-brain axis and probiotics in relation to migraines. The review concludes that the selection of an appropriate diet and obtaining correct dietary counseling is recommended to ensure the biopsychosocial well-being of migraine patients, as strict food avoidance may result in stress and poor quality of life.

Source:Migraine and Diet

How Can Fasting Help you Live a Longer, Healthier Life?

In this Goop podcast chief content officer at Goop, Elise Loehnen talks to Valter Longo, author of the longevity diet, as part of a series on detox, nutrition, and resetting the body. Longo is also one of the world’s leading experts on fasting. During the interview, they tackle questions such as “Is intermittent fasting the key to health?” Longo proposes fasting as one of the elements that contribute to longevity and to a healthy life, avoiding the diseases that often plague the elderly. The podcast also addresses the research surrounding the connection between fasting and preventing autoimmune diseases and cancer as well as the idea of making fasting part of standard cancer treatment. Longo discusses clinical trials including seven clinical trials supporting FMD (Fasting Mimicking Diet).

What you Should Know About your Diet and Warfarin

The blood-thinning medication, warfarin decreases the chance of harmful blood clots by blocking the effects of vitamin K which helps blood-clotting proteins form in the liver. Your warfarin dose is determined by your PT or INR measurements that show how long it takes for your blood to form clots.

A document published by ImpactTeam looks at how your diet affects warfarin and how the amount of vitamin K in your diet will determine the warfarin dose needed to prevent bleeding. Warfarin may have possible interaction with cranberry juice, mango juice, grapefruit juice, caffeine, charbroiled foods, alcohol, garlic, soy, ginger, and green tea. In addition, there is potential interaction of dietary supplements with warfarin.

Source: Warfarin and your Diet


Low‐Fat vs Ketogenic Diet for PD?

A 2018 study published in NCBI  aimed to compare the plausibility, safety, and efficacy of a low‐fat, high‐carbohydrate diet versus a ketogenic diet in PD patients. Primary outcomes were within‐ and between‐group changes in MDS‐UPDRS Parts 1 to 4 over 8 weeks. 47 patients were randomized, of which 44 commenced the diets and 38 completed the study (86% completion rate for patients commencing the diets). The ketogenic diet group maintained physiological ketosis. Both groups significantly decreased their MDS‐UPDRS scores, but the ketogenic group decreased more in Part 1 (−4.58 ± 2.17 points, representing a 41% improvement in baseline Part 1 scores) compared to the low‐fat group (−0.99 ± 3.63 points, representing an 11% improvement) (P < 0.001), with the largest between‐group decreases observed for urinary problems, pain and other sensations, fatigue, daytime sleepiness, and cognitive impairment. The trial found that It is plausible and safe for PD patients to maintain a low‐fat or ketogenic diet for 8 weeks. Both diet groups significantly improved in motor and nonmotor symptoms; however, the ketogenic group showed greater improvements in nonmotor symptoms.

Source: Low‐fat versus ketogenic diet in Parkinson’s disease: A pilot randomized controlled trial (© 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.)


Health Solutions Library for Critical Diseases Including PD

If you’re dealing with a chronic disease or you know someone who is then Chris Kresser’s Health Solutions Library can provide you with resources. Among the resources are books and ebooks that cover preventing and reversing chronic illness and guides for living a healthier life. There are also courses you can take in health care and articles focused on health written by leading specialists. Kresser offers an easy-to-use index to help you find the resources for your particular ailment.

Source: Health Solutions Library | Chris Kresser