Treatment of Mitochondrial Dysfunction with Natural Supplements

Mitochondrial dysfunction is common in PD. Mitochondria are organelle responsible for cellular energy production. Loss of function of mitochondria can lead to fatigue and other symptoms common in chronic diseases. A study in 2014 by Garth L. Nicolson, Ph.D. looked at how this can be avoided with natural supplements. Clinical trials have shown that using oral replacement supplements, such as L-carnitine, alpha-lipoic acid (α-lipoic acid [1,2-dithiolane-3-pentanoic acid]), coenzyme Q10(CoQ10 [ubiquinone]), reduced nicotinamide adenine dinucleotide (NADH), membrane phospholipids, and other supplements can naturally restore mitochondrial function. The study conducted regression analyses of data from participants using supplements to determine if fatigue was (1) consistent, (2) occurred with a high degree of confidence, and (3) could predict further reductions in fatigue.

The study concluded that oral natural supplements containing membrane phospholipids, CoQ10, microencapsulated NADH, l-carnitine, α-lipoic acid, and other nutrients can help restore mitochondrial function and reduce intractable fatigue in patients with chronic illnesses.

Source: Nicolson GL. Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements. Integr Med (Encinitas). 2014;13(4):35-43.

New Research on NIACIN vs NMN

A 2020 trial looks at the anti-aging effects of niacin. The key is to promote not only a longer life but a healthier life. As we age our NAD molecules decrease so that there is not enough fuel for Sirtuins enzymes that can help reverse DNA damage and signs of aging. One of the main reasons our NAD+ decreases is the enzyme CD38. CD38 is also involved in the degradation of the precursor to NAD, nicotinamide mononucleotide (NMN). As we age our CD38 levels increase and NAD+ go down. The less we activate our Sirtuins the more CD38 we have, so NAMPT suppresses CD38 expression via SIRT1. We can break this vicious circle by taking niacin which can create NAD+ so Sirtuins will have the fuel they need. The study notes that increased NAD+ levels remarkably improved disease hallmarks and mitochondrial mass. This is interesting for treating high cholesterol cases and chronic disease.

Here are the links to the research papers referenced in the video: www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/pubmed/3… www.ncbi.nlm.nih.gov/pubmed/3… www.ncbi.nlm.nih.gov/pubmed/1… www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/books/NB… www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/pmc/arti…

Some notes about niacin safety depending on HDL/LDL cholesterol levels:
abcnews.go.com/blogs/health/2011/11/15/niacin-statin-combo-offers-no-clinical-benefit-says-study/

pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000335#Possible%20Interactions

Big study showing the risk of high dose niacin + some cholesterol-lowering medication
www.cardiosmart.org/News-and-Events/2013/03/In-High-Doses-Niacin-Causes-More-Harm-than-Good#:~:text=After%20tracking%20patients%20for%20years,skin%20issues%2C%20and%20gastrointestinal%20problems.

High dose for treating cholesterol is normally 1-2 grams but may be as high as 12 grams

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr

Metformin 1 gr at night

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO content
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily

make a list according to this guy