Use of K₂ and Warfarin During Perioperative Period of Catheter Ablation

A study published in the Journal of Pharmaceutical Health Care in 2016 conducted population pharmacokinetic/pharmacodynamic modeling for retrospective clinical data to investigate the effect of vitamin K2on the anticoagulant activity of warfarin in the perioperative period of catheter ablation. 579 INR values of prothrombin time from 100 patients were analyzed using the nonlinear mixed-effects modeling program NONMEM. A 1-compartment model was adapted to the pharmacokinetics of warfarin and vitamin K2, and the indirect response model was used to investigate the relationship between plasma concentration and the pharmacodynamic response of warfarin and vitamin K2.

The population parameters obtained successfully explained the observed INR values and indicated an increase in sensitivity to warfarin in patients with reduced renal function. Vitamin K2 administration of more than 20 mg caused a slight dose-dependent decrease in INR on the day of catheter ablation and a delayed INR elevation after warfarin re-initiation. A pharmacokinetic/pharmacodynamic model was successfully built to explain the retrospective INR data during catheter ablation.

Source: Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

Could Coenzyme Q10 be Used as a Supplement for PD Patients?

A paper by Robert Alan Bonakdar, MD, and Erminia Guarneri MD, published by aafp.org in 2005 looks at coenzyme Q10 and its use in the treatment of a variety of disorders including PD, plus cardiac, immunologic, and oncologic conditions. Coenzyme Q10 appears to be a safe supplement with minimal side effects and low drug interaction potential. As yet, coenzyme Q10 has not been approved for the treatment of specific diseases in the USA. A randomized, double-blind, placebo-controlled, multicenter study of 80 patients found that 1,200 mg per day of coenzyme Q10 was associated with up to 44 percent less functional decline in patients with Parkinson’s disease, including activities of daily living. A study of 28 patients with Parkinson’s disease also demonstrated mild symptom improvement with daily oral dosing of 360 mg of coenzyme Q10. These results are awaiting confirmation.

Source: Coenzyme Q10 – American Family Physician

Vitamin K, as a Treatment, and its Interaction with Warfarin

An article published in U.S.Pharmacist in 2012 looks at the emerging role of K2. Recent research has found that vitamin K could be used to treat osteoporosis, cardiovascular diseases, and perhaps Alzheimer’s, skin aging, and various cancers. Vitamin K plays a role in regulating the healthy function of calcium and preventing pathologic calcification of the vessels and soft tissues. Vitamin K vitamers include K1 phytonadione; K2 menaquinone, and K3 menadione. The ability to convert vitamin K1 to K2 varies widely between species and breeds of animals. Vitamins K1 and K2 chemically share a common ring-structured nucleus but possess different types of side chains. Humans require dietary preformed vitamin K2 for optimal health, due to its superiority over K1 and for normal clotting of blood. The bones, liver, cartilage, and arterial walls can pull vitamin K from the blood. The current FDA recommendation is for the liver requirement only. Vitamin K antagonists include Warfarin, the blood-thinning drug that inhibits vitamin K-dependent clotting factors. Vitamin K can decrease the blood-thinning effects of warfarin and lower PT or INR value.

Source: The Emerging Role of Vitamin K2

 

What are the Benefits, Side Effects, and Uses of Resveratrol?

A study published in the MDPI journal Biomedicines in 2018 looked at the pros and cons of Resveratrol. Resveratrol has a wide range of beneficial properties; it is cardioprotective, an antioxidant, neuroprotective, has anti-cancer activities, and anti-inflammatory properties. However, its hydrophobic nature gives it limited bioavailability resulting from its poor water solubility. Resveratrol has not been found to have any side effects but this may depend on the dosage. Resveratrol can effectively­­­­ help with a number of conditions. Its neuroprotective properties can help with various neurogenerative conditions such as Alzheimer’s, Huntington’s, and PD. Although Resveratrol’s benefits are well documented some studies have shown that it may behave as a pro-oxidizing agent, thus it may also have implications in the pathology of several diseases.

Source: Resveratrol: A Double-Edged Sword in Health Benefits

Can you Take Fish Oil or Krill Oil Supplements with Warfarin Without Significantly Affect  the INR~

A study published in the MDPI journal Nutrients looks at the use of fish oil with warfarin and whether it significantly affects the INR or incidence of adverse events in patients. Warfarin is an anticoagulant often used to manage atrial fibrillation and deep vein thrombosis. However, patients have to be careful about drug interaction with warfarin. Fish and krill oil products are among the many complimentary medicines which have been flagged as having a potential interaction with warfarin. This study assesses the influence of fish and krill oil supplements on warfarin and looks at patients that took warfarin simultaneously with fish or krill oil. The result was that overall, the oils did not significantly alter the efficacy of warfarin.

Source: The Use of Fish Oil with Warfarin Does Not Significantly Affect either the International Normalised Ratio or Incidence of Adverse Events in Patients with Atrial Fibrillation and Deep Vein Thrombosis: A Retrospective Study

New Research on NIACIN vs NMN

A 2020 trial looks at the anti-aging effects of niacin. The key is to promote not only a longer life but a healthier life. As we age our NAD molecules decrease so that there is not enough fuel for Sirtuins enzymes that can help reverse DNA damage and signs of aging. One of the main reasons our NAD+ decreases is the enzyme CD38. CD38 is also involved in the degradation of the precursor to NAD, nicotinamide mononucleotide (NMN). As we age our CD38 levels increase and NAD+ go down. The less we activate our Sirtuins the more CD38 we have, so NAMPT suppresses CD38 expression via SIRT1. We can break this vicious circle by taking niacin which can create NAD+ so Sirtuins will have the fuel they need. The study notes that increased NAD+ levels remarkably improved disease hallmarks and mitochondrial mass. This is interesting for treating high cholesterol cases and chronic disease.

Here are the links to the research papers referenced in the video: www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/pubmed/3… www.ncbi.nlm.nih.gov/pubmed/3… www.ncbi.nlm.nih.gov/pubmed/1… www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/books/NB… www.ncbi.nlm.nih.gov/pmc/arti… www.ncbi.nlm.nih.gov/pmc/arti…

Some notes about niacin safety depending on HDL/LDL cholesterol levels:
abcnews.go.com/blogs/health/2011/11/15/niacin-statin-combo-offers-no-clinical-benefit-says-study/

pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000335#Possible%20Interactions

Big study showing the risk of high dose niacin + some cholesterol-lowering medication
www.cardiosmart.org/News-and-Events/2013/03/In-High-Doses-Niacin-Causes-More-Harm-than-Good#:~:text=After%20tracking%20patients%20for%20years,skin%20issues%2C%20and%20gastrointestinal%20problems.

High dose for treating cholesterol is normally 1-2 grams but may be as high as 12 grams

Megadose Vitamin C – As An Antiviral Treatment

A study published by the NIH Clinical Trials looked at vitamin C infusion as a possible treatment for severe COVID-infected pneumonia. The study was sponsored by ZhiYong Peng of the Zhongnan Hospital. The study hypothesized that vitamin C infusion could improve the prognosis of SARI (Severe acute respiratory infection)patients. 12g vitamin C was infused in the experimental group twice a day for 7 days by the infusion pump with a speed of 12ml/h. Early clinical studies have shown that vitamin C can effectively prevent the cytokine surge caused by sepsis, and neutrophils accumulation in the lungs destroying alveolar capillaries. In addition, vitamin C can help to eliminate alveolar fluid by preventing the activation and accumulation of neutrophils, and reducing alveolar epithelial water channel damage. At the same time, vitamin C can prevent the formation of neutrophil extracellular traps and shorten the duration of the common cold. In a controlled but non-randomized trial, 85% of the 252 students treated experienced a reduction in symptoms in the high-dose vitamin C group (1g / h at the beginning of symptoms for 6h, followed by 3 * 1g / day). Among patients with sepsis and ARDS, patients in the high-dose vitamin group did not show a better prognosis and other clinical outcomes.

Source: Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia

 

 

Vitamin D | Linus Pauling Institute | Oregon State University

n a randomized, double-blind, placebo-controlled study, 112 PD patients (mean age, 72 years) on standard PD treatment were supplemented with 1,200 IU/day of vitamin D or a placebo for 12 months. Vitamin D supplementation nearly doubled serum 25-hydroxyvitamin D concentration (from mean of 22.5 ng/mL to 41.7 ng/mL) in supplemented subjects and limited the progression of PD, as indicated by a greater proportion of patients who showed no worsening (as assessed by the Hoehn and Yahr stage and the United Parkinson Disease Rating Scale part II) in the supplemented group compared to the placebo group (243). It is not known whether vitamin D insufficiency has a role in the pathogenesis of the disease, but the repletion of vitamin D may provide health benefits that go beyond the prevention and/or the treatment of PD. For example, vitamin D deficiency may contribute to the increased risk of osteoporosis and bone fracture in individuals with neurologic disorders, including PD and multiple sclerosis (244-246). Interestingly, sunlight exposure was found to be associated with improved vitamin D status, higher bone mineral density of the second metacarpal bone, and lower incidence of hip fracture in a prospective study conducted in 324 elderly people with PD (247).

Source: Vitamin D | Linus Pauling Institute | Oregon State University

Over-the-counter Vitamin K1-containing Multivitamin Supplements Disrupt Warfarin Anticoagulation in Vitamin K1-depleted Patients. 

Most multivitamin supplements contain far less vitamin K(1) than thought to affect warfarin anticoagulation. Having described 3 patients with multivitamin-warfarin interactions, we hypothesized that vitamin K(1)-depleted patients are sensitive to even small increments. Therefore, we compared the eff …

Source: Over-the-counter Vitamin K1-containing Multivitamin Supplements Disrupt Warfarin Anticoagulation in Vitamin K1-depleted Patients. A Prospective, Controlled Trial – PubMed

Magnesium to prevent and reverse Aurtic stenosis and calcification in general

the SEM data show that the protein-protein cross-linking bonds are the starting sites of calcification. In addition, substitution of Ca2+ cations by Mg2+ cations leads to the formation of amorphous hydroxyapatite, preventing aortic valve stenosis, which suggests that treatment with magnesium salts may reduce stenosis of aortic valves…
iv.iiarjournals.org/content/28/1/91.full

We observed strong, favorable associations between higher self-reported total (dietary and supplemental) magnesium intake and lower calcification of the coronary arteries…
www.ncbi.nlm.nih.gov/pmc/articles/PMC3957229/

Studies showed that a calcium to magnesium intake ratio <2.8 is critical for optimal health, supporting a long-held but non–evidence-based recommendation that the calcium to magnesium ratio should be close to 2. Increasing calcium intakes in the United States since 1977 have resulted in a calcium to magnesium ratio >3.0 since 2000, coinciding with increasing rates of T2D and colorectal cancer. US studies assessing oral magnesium therapy or dietary magnesium intakes showed beneficial effects of dietary magnesium in CVD, T2D, and cancers, although similar studies in populations with lower calcium to magnesium ratios (≥1.7) reported the opposite…
www.ncbi.nlm.nih.gov/pmc/articles/PMC4717874/

 

Ketosis and Ketosis Supplements

  •  high-fat, low-carb keto diet. Being in ketosis, the state where your body uses fat instead of glucose for energy, increases the NAD+ to NADH ratio. You want higher NAD+, because it protects cells from oxidative stress[20][21] — an imbalance between free radicals and antioxidants in your body that contributes to aging.[22][23]
  • Practice intermittent fasting. Restricting your eating increases NAD+ levels.[24][25] Though calorie-restriction diets and periods of fasting will do it, those aren’t sustainable for the long term. Intermittent fasting is, if you do it right. Here’s how to get started with intermittent fasting.
  • Take oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate.

NADD+ and NADH

NADH for PD:

(NADH) has been used as medication in 885 PD patients in an open label trial. About half of the patients received NADH by intravenous infusion, the other part orally by capsules. In about 80% of the patients a beneficial clinical effect was observed

NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344

older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf

NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh

NR+?

Most sources say boost  NAD+ using precursors or NAD+ supplement (NMN, NR)

also oxaloacetate :

oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate

see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x

NAD+

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

NADH for PD:

short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…

liposomal NMN ?

all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)

Metformin 1 gr at night (checkout supplement alternative Berberine )

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily

make a list according to this guy

checkout Uleic vs resveratrol

Risk:

Metformin may increase risk of PD and other neurodegenerative disease

Leaky Gut protocol

Tom Obrian:

Vitamin D
Glutamine
Fish Oil 3gr per day
Zinc carnosine 2X75 mg /day
Colestrum
Probiotics

use coconut oil – oil pulling  , for mouth higene, especially against gingivalis

 

list of leaky gut treatment options on slefhacked

see also postt on colostrun, here

in normal physiology, glutamine plays a key role in signalling in enterocytes that are part of the intestinal barrier, but it is not clear if supplementing the diet with glutamine is helpful in conditions where there is increased intestinal permeability.[27]

Prebiotics and certain probiotics such as Escherichia coli Nissle 1917 have been found to reduce increased intestinal permeability.[9] Lactobacillus rhamnosus,[28] Lactobacillus reuteri,[28] and Faecalibacterium prausnitzii[29] have also been shown to significantly reduce increased intestinal permeability.

Larazotide acetate (previously known as AT-1001) is a zonulin receptor antagonist that has been probed in clinical trials. It seems to be a drug candidate for use in conjunction with a gluten-free diet in people with celiac disease, with the aim to reduce the intestinal permeability caused by gluten and its passage through the epithelium, and therefore mitigating the resulting cascade of immune reactions.[25][30] read more>>

Colostrum, for leaky gut

positive results of colostrum on adult gut health in several recent well controlled published studies.[44][45][46][47]

Davison, Glen; Marchbank, Tania; March, Daniel S.; Thatcher, Rhys; Playford, Raymond J. (1 August 2016). “Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers”. The American Journal of Clinical Nutrition. 104 (2): 526–536. doi:10.3945/ajcn.116.134403. ISSN 1938-3207. PMID 27357095.
Marchbank, Tania; Davison, Glen; Oakes, Jemma R.; Ghatei, Mohammad A.; Patterson, Michael; Moyer, Mary Pat; Playford, Raymond J. (1 March 2011). “The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes”. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300 (3): G477–484. doi:10.1152/ajpgi.00281.2010. ISSN 1522-1547. PMID 21148400.
Playford, R. J.; MacDonald, C. E.; Calnan, D. P.; Floyd, D. N.; Podas, T.; Johnson, W.; Wicks, A. C.; Bashir, O.; Marchbank, T. (1 June 2001). “Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability”. Clinical Science (London, England: 1979). 100 (6): 627–633. ISSN 0143-5221. PMID 11352778.
Khan, Z.; Macdonald, C.; Wicks, A. C.; Holt, M. P.; Floyd, D.; Ghosh, S.; Wright, N. A.; Playford, R. J. (1 November 2002). “Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study”. Alimentary Pharmacology & Therapeutics. 16 (11): 1917–1922. ISSN 0269-2813. PMID 12390100.
Uruakpa, F; Ismond, M.A.H; Akobundu, E.N.T (2002). “Colostrum and its benefits: a review”. Nutrition Research. 22 (6): 755–767. doi:10.1016/S0271-5317(02)00373-1.

research list on examine.com

get Colostrum on Iherb