Perspective on the Road toward Gene Therapy for Parkinson’s Disease

Source: Perspective on the Road toward Gene Therapy for Parkinson’s Disease

Results from the clinical trials may at a first look seem somewhat disappointing, but have brought the field to a state that safe delivery of viral vectors into the brain is feasible. Expression of a foreign (therapeutic) gene is possible and in none of the studies, long term exposure to the transgene has led to severe adverse events. With such a progression, delivery of the silver bullet still seems within reach.