Leaky Gut protocol

Tom Obrian:

Vitamin D
Fish Oil 3gr per day
Zinc carnosine 2X75 mg /day

use coconut oil – oil pulling  , for mouth higene, especially against gingivalis


list of leaky gut treatment options on slefhacked

see also postt on colostrun, here

in normal physiology, glutamine plays a key role in signalling in enterocytes that are part of the intestinal barrier, but it is not clear if supplementing the diet with glutamine is helpful in conditions where there is increased intestinal permeability.[27]

Prebiotics and certain probiotics such as Escherichia coli Nissle 1917 have been found to reduce increased intestinal permeability.[9] Lactobacillus rhamnosus,[28] Lactobacillus reuteri,[28] and Faecalibacterium prausnitzii[29] have also been shown to significantly reduce increased intestinal permeability.

Larazotide acetate (previously known as AT-1001) is a zonulin receptor antagonist that has been probed in clinical trials. It seems to be a drug candidate for use in conjunction with a gluten-free diet in people with celiac disease, with the aim to reduce the intestinal permeability caused by gluten and its passage through the epithelium, and therefore mitigating the resulting cascade of immune reactions.[25][30] read more>>

mutant (A53T) α-synuclein exhibit impaired autonomic regulation of heart rate characterized by elevated resting heart rate

Mutations in α-synuclein cause some cases of familial PD. Several lines of transgenic mice that overexpress wild type or mutant human α-synuclein exhibit progressive accumulation of α-synuclein in neurons, motor dysfunction and death (). Mice expressing mutant (A53T) α-synuclein exhibit impaired autonomic regulation of heart rate characterized by elevated resting heart rate associated with accumulation of α-synuclein aggregates in the brainstem and reduced parasympa-thetic (cardiovagal) tone (). Maintenance of the α-synuclein mutant mice on ADF reversed the autonomic deficit, whereas a high fat diet exacerbated the autonomic deficit (). Consistent with the latter findings, a high fat diet hastened the onset of motor dysfunction and brainstem pathology in another line of α-synuclein mutant mice, which was associated with reduced activity of kinases known to be involved in neurotrophic factor signaling (). In addition to enhancement of neurotrophic factor/BDNF signaling, IF may counteract PD-related pathogenic processes by stimulating autophagy. Indeed, inhibition of mTOR with rapamycin, which stimulates autophagy, reduced oxidative stress and synaptic damage, and improved motor function in a α-synuclein accumulation-based mouse model of PD ().

full article intermittent fasting >> 




magnesium deficiency can cause hreart palpatation and also calcification of heart and blood vessle

general association between magnesium and heart health www.ncbi.nlm.nih.gov/pmc/articles/PMC3957229/

 magnesium salts  could reduce the progress of aortic valve stenosis 


Forced exercise 35% improvement, motor learning ? upregulate dopamine



motor learning activated by stressor – speed, to adapt to the stressor,result is speed and performance when in speed

i assume it goes both ways and e.g. Zen meditation will slow onedown, also depresion/LH/static job

possible treatment -external speed (treadmill),external speed  /pulse measurement


I speculate that high intensity over continues period of time develops (up regulate) dopamine secretion. that includes brain games

Insulin Resistance, GLP-1 analogues, Incretin Mimetics for AD and PD

AD – See Bredesen

PD –
A pilot study in PD patients testing a GLP-1 receptor agonist that is currently on the market as a treatment for type 2 diabetes (exendin-4, Byetta) also showed encouraging effects. Several other clinical trials are currently ongoing in AD patients, testing another GLP-1 analogue that is on the market (liraglutide, Victoza). Recently, a third GLP-1 receptor agonist has been brought to the market in Europe (Lixisenatide, Lyxumia), which also shows very promising neuroprotective effects. This review will summarise the range of these protective effects that those drugs have demonstrated. GLP-1 analogues show promise in providing novel treatments that may be protective or even regenerative in AD and PD, something that no current drug does.
Drugs developed for treatment of diabetes show protective effects in Alzheimer’s and Parkinson’s diseases.

Drugs developed for treatment of diabetes show protective effects inAlzheimer’s and Parkinson’s diseases – full text review


חקייני אינקרטין (Incretin Mimetics)


See Ronda Patrick


related treatment option for PD  see https://1.getmanaged.online/nly01-halts-pd/


neuroprotective effect of nicotine and coffee in PD and AD

Dr Andrue Huberman – Nicotine can hold off certain types of PD and AD, and it also increase neuroplacticity


more information:

Neuroprotective effect of nicotine
A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease. 


Modifiable Risk Factors of Parkinson’s Disease (multiple studies)
byu/magic-theater inCholinergicHypothesis