Infographic all PD clinical trials in phase 1-3 2021 >>
PD Drug Therapies in the Clinical Trial Pipeline: 2021 Update >>
we suggest that LSVT encourages acceptance of and comfort with increased loudness and the ability to self-monitor vocal loudness. Addressing this apparent sensory mismatch between vocal effort and vocal output may contribute to generalization and maintenance of treatment effects. Finally, treatment that is simple, redundant, and intensive may help accommodate the processing speed, memory, and executive function deficits observed in some individuals with IPD. It may also promote overlearning and internalization of the vocal effort required for normal loudness
pubs.asha.org/doi/full/10.1044/1058-0360%282002/012%29
Our 15 years of research have generated the first short- and long-term efficacy data for speech treatment (Lee Silverman Voice Treatment; LSVT/LOUD) in Parkinson’s disease. We have learned that training the single motor control parameter amplitude (vocal loudness) and recalibration of self-perception of vocal loudness are fundamental elements underlying treatment success. This training requires intensive, high-effort exercise combined with a single, functionally relevant target (loudness) taught across simple to complex speech tasks. We have documented that training vocal loudness results in distributed effects of improved articulation, facial expression, and swallowing. Furthermore, positive effects of LSVT/LOUD have been documented in disorders other than Parkinson’s disease (stroke, cerebral palsy). The purpose of this article is to elucidate the potential of a single target in treatment to encourage cross-system improvements across seemingly diverse motor systems and to discuss key elements in mode of delivery of treatment that are consistent with principles of neural plasticity.
www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-955118
repeated sessions of caloric vestibular stimulation (CVS) relieved motor and non-motor symptoms associated with Parkinson’s disease (PD).
www.prd-journal.com/article/S1353-8020(19)30252-4/fulltext
Mike Mutzel from High Intensity Health (author of Belly Fat Effect) talks to Frank Llosa of KetoneAid. KetoneAid produces a Ketone Ester (raw beta-hydroxybutyrate (BHB) ketone) supplement that can get you into a deep state of ketosis within 30 minutes. You would have to fast or go on an intense ketogenic diet to reach the same ketosis state. There are different types of Keto testing, blood glucose testing, and different types of exogenous Ketones. Ketosis is influenced by BHB salts; Ketone supplements. There have been many discussions about the link between PD and the ketogenic diet. In one study PD patients were put on a ketogenic diet for a month and the results showed a 43% improvement in the Unified Parkinson’s Disease rating scale. There is no doubt that PD is affected by diet and nutrition so the ketogenic diet may offer relief from some symptoms.
This 2020 NCBI meta-analysis takes a close look at prebiotics which play a role in augmenting the presence of gut microbiota such as Bifidobacterium, Clostridium, Bacteroidetes, and Lactobacilli which have been demonstrated in functional gastrointestinal disorders. There are only a few studies of the efficacy of prebiotics for chronic constipation and the utility of different commercially available prebiotics in patients with functional and chronic idiopathic constipation. 21 randomized controlled trials were reviewed showing prebiotics to be effective treatments for chronic idiopathic constipation; improvement in stool consistency; the number of bowel moments, and bloating.
Source: Therapeutic Effects of Prebiotics in Constipation: A Review – PubMed
yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019
The product containing yogurt with polydextrose, B. lactis HN019 and L. acidophilus NCFM® significantly shortened colonic transit time after two weeks
Meta analysis: Bifidobacterium lactis works best, Lactobacillus casei Shirota not so good