PBM – photobiomodulation for PD

In 2008, the researchers in Wisconsin, US discovered that PBM (photobiomodulation) is effective on Parkinson’s ( Liang et al., 2008 ). Click to view
Afterwards, researchers in Australia, France and Switzerland published numerous research studies that PBM can reduce the symptoms of MPTP and/or 6-OHDA and alpha-synuclein in the animal model with Parkinson’s (Johnstone et al., 2016 ). Click to view
In 2016, the study on PBM having an effect on monkey model with Parkinson’s has been published in the Annals of Neurology in the American Journal of Neurology. Click to view
In this study, optical fiber devices with visible red light (670 nm) were planted in the brain and MPTP injections were given for a week. In this treatment, the majority of monkeys reversed the symptoms. ( Darlot et al., 2016 ).
Red light (670 nm) was used in this study, but near-infrared light (810 nm) was also used in other studies. Usually light is administered either as a span or as a straight line to the head through percutaneous fibers, but one study suggests that it has a remote neurological protection effect on the brain and that photobiotics may be better represented. ( Johnstone et al., 2014 , Kim et al 2017 ).
View article 1 View article 2
Please click here to read more studies on PBM therapy and Parkinson’s

Source: PBM

PD and basal ganglia calcifications

We reviewed computerized tomograms (CT) for basal ganglia and dentate nucleus calcifications in 79 patients with Parkinson’s disease (PD), 54 patients with Alzheimer’s disease (AD) and 109 controls aged 50 or more. When it was determined, no patient had disturbances in calcium metabolism. We found: …

Source: Parkinson’s disease and basal ganglia calcifications: prevalence and clinico-radiological correlations – PubMed

Fountain Life  – lab, life force – Tony Robins 

Fountain Life brings together the world’s most renowned medical and health experts to boost longevity and performance. Our goal is to educate our members and empower them to be proactive about their health. We help our members operate at peak performance throughout their lifespan! We strive to help our members make 100 the new 60.

Source: Performance Optimization | Fountain Life

PD – Functional medicine – Dr. Adiel Tel-Oren

A chronic progressive CNS disorder characterized by slowness of purposeful movement, resting tremors, and muscle rigidity.  Also called “Parkinsonism” and “Paralysis Agitans” Dorland’s Medical Dictionary describes the Parkinsonian complex as “neurologic disorders characterized by hypokinesia, tremors and muscular rigidity. It typically occurs late in life, although juvenile forms have been described.” The diagnosis for their disorder is made from the

Source: Ecopolitan – Parkinson’s Disease – Functional medicine – Dr. Adiel Tel-Oren

Parkinson’s disease treated with Sinemet or Madopar. A controlled multicenter trial – PubMed

92 patients with Parkinson’s disease not previously treated with levodopa were considered as eligible for this triple-blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar) or levodopa + carbidopa ratio 10:1 (Sinemet) using dosage schedules …

Source: Parkinson’s disease treated with Sinemet or Madopar. A controlled multicenter trial – PubMed

Effects of tyramine administration in Parkinson’s disease patients treated with selective MAO-B inhibitor rasagiline – PubMed

Rasagiline is a novel, potent, and selective MAO-B inhibitor shown to be effective for Parkinson’s disease. Traditional nonselective MAO inhibitors have been associated with dietary tyramine interactions that can induce hypertensive reactions. To test safety, tyramine challenges (50-75 mg) were perf …

Source: Effects of tyramine administration in Parkinson’s disease patients treated with selective MAO-B inhibitor rasagiline – PubMed

Dietary Plant Lectins transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease  

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease

Source: Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease – PMC

The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease  

Results: Skin biopsies provide >90% sensitivity and >90% specificity to distinguish PD from control participants across all biopsies sites with quantification of either pilomotor or sudomotor α-synuclein deposition. All individuals with PD have significantly higher cutaneous α-synuclein deposition than control participants, even those individuals with PD and no evidence of autonomic dysfunction. Deposition of α-synuclein is most prominent in sympathetic adrenergic nerve fibers innervating the arrector pili muscles, but is also present in sudomotor (sympathetic cholinergic) nerve fibers. α-Synuclein is present even in the early stages of disease and disease of short duration. α-Synuclein ratios were higher in individuals with autonomic failure, with more advanced stages of disease and disease of longer duration.Conclusions: The α-synuclein ratio provides a sensitive and specific diagnostic biomarker of PD even in patients without autonomic failure.Classification of evidence: This study provides Class III evidence that cutaneous α-synuclein deposition accurately identifies patients with PD.

Source: The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease – PMC

 

  • So seems that sweat glands are secreting alpha-synuclein, could sweating be used to detox or to normalize levels of alpha-synuclein

Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older Adults  

ognitive benefit of acute WGOE supplementation does not persist with chronic treatment

Source: Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older Adults: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial – PMC

Seems that cognitive benefit of green oat supplementation does not persist over time

strict ketogenic diets vs Keto light versions

For Indians, it appears that it would be most prudent to have a diet with about 50 per cent carbohydrate (using complex carbs and whole grains such as brown rice or whole wheat) about 20-25 per cent protein (preferably from vegetable proteins such as legumes and pulses) and the remaining 25-30 per cent from healthy fats like monounsaturated fats (e.g. groundnut oil or mustard oil and nuts and seeds) along with plenty of green leafy vegetables. Such a diet may not immediately give dramatic results as far as weight reduction is concerned. However, it will be sustainable in the long term and will be less risky and certainly more healthy and also help prevent non-communicable diseases such as diabetes, cardiovascular disease and certain cancers.

Source: Ketogenic diets: Boon or bane? – PMC