The Gordian knot of Parkinsons and clues that helps us solve it.
Source: Connect the dots » HOPE Shortcut
The Gordian knot of Parkinsons and clues that helps us solve it.
Source: Connect the dots » HOPE Shortcut
Introduction
discussuion on reddit
Any thoughts on the Vibration Gloves?
by u/cicla in Parkinsons
few notes
according to the video, the glove treatment is very affective, some results show after 1 day, at least for some people the effect of symptom reduction is amazing, this suggest that the cause of symptoms was not massive dopaminergic cell death but instead, dysregulation of dopaminergic cells that disrupted dopamine production
the developer of the treatment looks at the problem (PD..dopaminergic cells not releasing dopamine) from a systems perspective, and develop a way to reset existing dysregulation (or more specifically disrupt synchronization – a process in which one cell type sync other cell types, to behave like it )
it’s a way to reboot/restart to prevent accumulation of processing errors. actually it’s more targeted then a general restart. Maybe Electroconvulsive therapy, more suitable “reset” option ..some evidence >>
for example, you can solve most Windows errors simply by rebooting it. If you had to dive into some window issue (e.g. computer hanging, slow, printer messed, weird error message, apps installed don’t work..) well, not a realistic goal
so, when looking at parkinson’s from a system approach perspective, a good start would be to find a way to reboot you system
this will not solve all issues, e.g. if you got PD from exposure to a toxin rebooting your system will not to much
same with windows, if you got a computer virus and it’s causing issue. a reboot might not be sufficient
but in case a particular sequence of events is not handled well by the system and cause an error situation with lasting effect.. reboot might help as long as you don’t repeat that sequence
in my case, many years ago, I lost my sense of smell, at the time, I theorized that my intuition took over some of the neurons dedicated to the processing of smell, intuition was one of my mostly used “modules” ( see Meir Briges type classifier, this personality type classification is based on identifying the main modules used’ e.g thinking/sensing/feeling/intuiting)
We studied 10 regular exercising men with Parkinson’s disease on levodopa (LD) under two conditions–no exercise and vigorous exercise started 1 hour after LD ingestion. We compared LD levels and motor scores on the Unified Parkinson’s Disease Rating Scale (UPDRS). There was a high degree of agreeme …
Lab-grown nerve cells will replace those destroyed by disease – scientists hope treatment may be available in five years
Source: Radical new therapy for Parkinson’s will use stem cell transplants
STEM-PD trial 2024, 1 year after 4 succesful transpalnts out of for, now major side effects, and 4 more transplants done with higher dose, they will monitor the outcome for 3 years
STEM-PD, a cell-replacement trial for Parkinson’s, releases latest update
Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application
The most pressing need in Parkinson’s disease (PD) clinical practice is to identify agents that might slow down, stop or reverse the neurodegenerative process of Parkinson’s disease and therefore avoid the onset of the most disabling, dopa-refractory symptoms of the disease. These include dementia, …
Many studies show that low-carb and ketogenic diets can lead to dramatic weight loss and improve most major risk factors for heart disease and diabetes. Also, repeatedly shown (but not always) to help with or reverse PD and other neurologicsal conditions
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The need for therapies that change the course of Parkinson’s disease is considerable. Several contenders are in development.
We reviewed computerized tomograms (CT) for basal ganglia and dentate nucleus calcifications in 79 patients with Parkinson’s disease (PD), 54 patients with Alzheimer’s disease (AD) and 109 controls aged 50 or more. When it was determined, no patient had disturbances in calcium metabolism. We found: …