Leaky Gut protocol

Tom Obrian:

Vitamin D
Glutamine
Fish Oil 3gr per day
Zinc carnosine 2X75 mg /day
Colestrum
Probiotics

use coconut oil – oil pulling  , for mouth higene, especially against gingivalis

 

list of leaky gut treatment options on slefhacked

see also postt on colostrun, here

in normal physiology, glutamine plays a key role in signalling in enterocytes that are part of the intestinal barrier, but it is not clear if supplementing the diet with glutamine is helpful in conditions where there is increased intestinal permeability.[27]

Prebiotics and certain probiotics such as Escherichia coli Nissle 1917 have been found to reduce increased intestinal permeability.[9] Lactobacillus rhamnosus,[28] Lactobacillus reuteri,[28] and Faecalibacterium prausnitzii[29] have also been shown to significantly reduce increased intestinal permeability.

Larazotide acetate (previously known as AT-1001) is a zonulin receptor antagonist that has been probed in clinical trials. It seems to be a drug candidate for use in conjunction with a gluten-free diet in people with celiac disease, with the aim to reduce the intestinal permeability caused by gluten and its passage through the epithelium, and therefore mitigating the resulting cascade of immune reactions.[25][30] read more>>

Colostrum, for leaky gut

positive results of colostrum on adult gut health in several recent well controlled published studies.[44][45][46][47]

Davison, Glen; Marchbank, Tania; March, Daniel S.; Thatcher, Rhys; Playford, Raymond J. (1 August 2016). “Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers”. The American Journal of Clinical Nutrition. 104 (2): 526–536. doi:10.3945/ajcn.116.134403. ISSN 1938-3207. PMID 27357095.
Marchbank, Tania; Davison, Glen; Oakes, Jemma R.; Ghatei, Mohammad A.; Patterson, Michael; Moyer, Mary Pat; Playford, Raymond J. (1 March 2011). “The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes”. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300 (3): G477–484. doi:10.1152/ajpgi.00281.2010. ISSN 1522-1547. PMID 21148400.
Playford, R. J.; MacDonald, C. E.; Calnan, D. P.; Floyd, D. N.; Podas, T.; Johnson, W.; Wicks, A. C.; Bashir, O.; Marchbank, T. (1 June 2001). “Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability”. Clinical Science (London, England: 1979). 100 (6): 627–633. ISSN 0143-5221. PMID 11352778.
Khan, Z.; Macdonald, C.; Wicks, A. C.; Holt, M. P.; Floyd, D.; Ghosh, S.; Wright, N. A.; Playford, R. J. (1 November 2002). “Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study”. Alimentary Pharmacology & Therapeutics. 16 (11): 1917–1922. ISSN 0269-2813. PMID 12390100.
Uruakpa, F; Ismond, M.A.H; Akobundu, E.N.T (2002). “Colostrum and its benefits: a review”. Nutrition Research. 22 (6): 755–767. doi:10.1016/S0271-5317(02)00373-1.

research list on examine.com

get Colostrum on Iherb

Magnesium

www.naturalstacks.com/blogs/news/magnesium

www.naturalnews.com/046401_magnesium_dietary_supplements_nutrient_absorption.html

magnesium deficiency can cause hreart palpatation and also calcification of heart and blood vessle

general association between magnesium and heart health www.ncbi.nlm.nih.gov/pmc/articles/PMC3957229/

 magnesium salts  could reduce the progress of aortic valve stenosis 

 

Insulin Resistance, GLP-1 analogues, Incretin Mimetics for AD and PD

Brain
AD – See Bredesen

PD –
A pilot study in PD patients testing a GLP-1 receptor agonist that is currently on the market as a treatment for type 2 diabetes (exendin-4, Byetta) also showed encouraging effects. Several other clinical trials are currently ongoing in AD patients, testing another GLP-1 analogue that is on the market (liraglutide, Victoza). Recently, a third GLP-1 receptor agonist has been brought to the market in Europe (Lixisenatide, Lyxumia), which also shows very promising neuroprotective effects. This review will summarise the range of these protective effects that those drugs have demonstrated. GLP-1 analogues show promise in providing novel treatments that may be protective or even regenerative in AD and PD, something that no current drug does.
Drugs developed for treatment of diabetes show protective effects in Alzheimer’s and Parkinson’s diseases.

Drugs developed for treatment of diabetes show protective effects inAlzheimer’s and Parkinson’s diseases – full text review

www.ncbi.nlm.nih.gov/pubmed/28927992

חקייני אינקרטין (Incretin Mimetics)

Heart:

Gut
See Ronda Patrick

 

related treatment option for PD  see https://1.getmanaged.online/nly01-halts-pd/

 

Longevity diet + Long fast (fmd), Intermintent fasting 5:2 16:8

vegetarian, no sugar, good oils, low protein, small fish

FMD see >>

see chapter 4 in the book

FMD –  file 28 longevity diet audiobook

research by longo regarding many conditions that benefit from periodic fasting

homemade FMD:

My Experience with the 5-Day Fasting Mimicking Diet

Dr Mattson research and recommendations 5:2 and 16:8

According to research conducted by neuroscientist Mark Mattson and others, cutting your energy intake by fasting several days a week might help your brain ward off neurodegenerative diseases like Alzheimer’s and Parkinson’s while at the same time improving memory and mood.

5:2 diet…every time you eat, glucose is stored in your liver as glycogen, which takes about 10 to 12 hours to be depleted. After the glycogen is used up, your body starts burning fats, which are converted to ketone bodies, acidic chemicals used by neurons as energy. Ketones promote positive changes in the structure of synapses important for learning, memory, and overall brain health. But if you eat three meals a day with snacks between, your body doesn’t have the chance to deplete the glycogen stores in your liver, and the ketones aren’t produced. Mattson says exercise can also get your body to lower its glycogen levels, and not coincidentally, exercise has been shown to have the same positive effects on brain health as fasting.

5:2 diet…when the brain is challenged by physical exertion, cognitive tasks, or caloric restriction, the body produces a protein called BDNF (brain-derived neurotrophic factor), which not only strengthens neural connections and increases the production of new neurons but can also have an anti-depressive effect.

see also Dr Fung on treating insulin resistance with low carb + fasting

IDM Program

 

 

 

Heavy metal Detox, Chealation, the cube, by Quick silver, Mercury, Led

check the full interview (not done yet)

summery:

get tested at Q-silver for a bundle including mercury

test for retention toxicity (kidney damage)`

leaky gut + high mercury => damage

sea food, get the small fish (down the food chain)

inhalation mercury, not a big problem

GI inflammation => more toxins secreted through the kidney, cause kidney overload

if you then try to chealate, more damage occur

first restore Liver-GI path, main mercury excretion is through fecal meter

Binders:
heavy metal – IMG,Chlorela …
endotoxins binders – charchol (get most micotoxins, except Aflatoxins)

Aflatoxins (by fungi), mold toxins -clay

1 getting the drainage to work (kidney, liver-GI)

a support GI with the above binders
b liver support Dendeline + milk thistele, as tea (herbs) or supplement e.g Now Silymarin , Bitters
3 kidney – Solidogo (golden rode) is best, cranberry (diuretic) get diuretics like tea and coffee+ drink a lot

2 moving the heavy metal out of the cell (gene up-regulation)

2 stages:

get glutataion(lipozomal or precursors)

NRF2 up regulation boost glutataion s transferese which gets stuff from the cell to the glutataion:

a r-lipoic acid
b polypanols
c sulfor based compounds (from crucifix, garlic, onion and other alliums)

pulse when up regulating gene expression

e.g. 5 days on 2 days of

MEPF|PEMF detox whats this?