www.ncbi.nlm.nih.gov/pubmed/10398297
2-deoxy-D-glucose (2-DG; a nonmetabolizable analogue of glucose) to mice fed ad libitum. Mice receiving 2-DG exhibited reduced damage to dopaminergic neurons in the SN and improved behavioral outcome following MPTP treatment.
Tom Obrian:
Vitamin D
Glutamine
Fish Oil 3gr per day
Zinc carnosine 2X75 mg /day
Colestrum
Probiotics
use coconut oil – oil pulling , for mouth higene, especially against gingivalis
list of leaky gut treatment options on slefhacked
see also postt on colostrun, here
in normal physiology, glutamine plays a key role in signalling in enterocytes that are part of the intestinal barrier, but it is not clear if supplementing the diet with glutamine is helpful in conditions where there is increased intestinal permeability.[27]
Prebiotics and certain probiotics such as Escherichia coli Nissle 1917 have been found to reduce increased intestinal permeability.[9] Lactobacillus rhamnosus,[28] Lactobacillus reuteri,[28] and Faecalibacterium prausnitzii[29] have also been shown to significantly reduce increased intestinal permeability.
Larazotide acetate (previously known as AT-1001) is a zonulin receptor antagonist that has been probed in clinical trials. It seems to be a drug candidate for use in conjunction with a gluten-free diet in people with celiac disease, with the aim to reduce the intestinal permeability caused by gluten and its passage through the epithelium, and therefore mitigating the resulting cascade of immune reactions.[25][30] read more>>
Davison, Glen; Marchbank, Tania; March, Daniel S.; Thatcher, Rhys; Playford, Raymond J. (1 August 2016). “Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers”. The American Journal of Clinical Nutrition. 104 (2): 526–536. doi:10.3945/ajcn.116.134403. ISSN 1938-3207. PMID 27357095.
Marchbank, Tania; Davison, Glen; Oakes, Jemma R.; Ghatei, Mohammad A.; Patterson, Michael; Moyer, Mary Pat; Playford, Raymond J. (1 March 2011). “The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes”. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300 (3): G477–484. doi:10.1152/ajpgi.00281.2010. ISSN 1522-1547. PMID 21148400.
Playford, R. J.; MacDonald, C. E.; Calnan, D. P.; Floyd, D. N.; Podas, T.; Johnson, W.; Wicks, A. C.; Bashir, O.; Marchbank, T. (1 June 2001). “Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability”. Clinical Science (London, England: 1979). 100 (6): 627–633. ISSN 0143-5221. PMID 11352778.
Khan, Z.; Macdonald, C.; Wicks, A. C.; Holt, M. P.; Floyd, D.; Ghosh, S.; Wright, N. A.; Playford, R. J. (1 November 2002). “Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study”. Alimentary Pharmacology & Therapeutics. 16 (11): 1917–1922. ISSN 0269-2813. PMID 12390100.
Uruakpa, F; Ismond, M.A.H; Akobundu, E.N.T (2002). “Colostrum and its benefits: a review”. Nutrition Research. 22 (6): 755–767. doi:10.1016/S0271-5317(02)00373-1.
Short, simplified video guide
Audio version:
www.amazon.com/dp/B07BR3LZW7/ref=dbs_p_adbl_dam
Printed version:
Also recomended, what ever you find relevant on hubermanlab.com
hubermanlab.com/
e.g fasting, metabolism…
Corynoxine, isolated from Uncaria rhynchophylla, promotes the clearance of alpha-synuclein
www.ncbi.nlm.nih.gov/pubmed/24522518
Corynoxine, isolated from Uncaria rhynchophylla, promotes the clearance of alpha-synuclein via mTOR pathway [R].
use of Uncaria rhynchophylla, known as “Gou-teng” herb extract
examine.com/supplements/uncaria-rhynchophylla/
www.ncbi.nlm.nih.gov/pubmed/29940559
buy uncaria-rhynchophylla:
buy Corynoxine:
www.alibaba.com/trade/search?fsb=y&IndexArea=product_en&CatId=&SearchText=Corynoxine
Action item:
q10 1200mg/day
Creatine
type 2 diabetes is associated with an increased risk of Parkinson’s disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and disease is not known
care.diabetesjournals.org/content/early/2007/01/24/dc06-2011.short
Mutations in α-synuclein cause some cases of familial PD. Several lines of transgenic mice that overexpress wild type or mutant human α-synuclein exhibit progressive accumulation of α-synuclein in neurons, motor dysfunction and death (Crabtree and Zhang, 2012). Mice expressing mutant (A53T) α-synuclein exhibit impaired autonomic regulation of heart rate characterized by elevated resting heart rate associated with accumulation of α-synuclein aggregates in the brainstem and reduced parasympa-thetic (cardiovagal) tone (Griffioen et al., 2013). Maintenance of the α-synuclein mutant mice on ADF reversed the autonomic deficit, whereas a high fat diet exacerbated the autonomic deficit (Griffioen et al., 2013). Consistent with the latter findings, a high fat diet hastened the onset of motor dysfunction and brainstem pathology in another line of α-synuclein mutant mice, which was associated with reduced activity of kinases known to be involved in neurotrophic factor signaling (Rotermund et al., 2014). In addition to enhancement of neurotrophic factor/BDNF signaling, IF may counteract PD-related pathogenic processes by stimulating autophagy. Indeed, inhibition of mTOR with rapamycin, which stimulates autophagy, reduced oxidative stress and synaptic damage, and improved motor function in a α-synuclein accumulation-based mouse model of PD (Bai et al., 2015).
