New treatments for PD, in trials

direct administration to the brain (that’s new) of GDNF  (also new)

The FDA granted approval of Nourianz to Kyowa Kirin, Inc.

  • A universal feature of Parkinson’s is aggregation, or clumping, of the protein alpha-synuclein in the brains and body cells of people with the disease (similar to the amyloid clumps seen in Alzheimer’s disease). Multiple drug companies are conducting clinical trials to try to prevent or break up synuclein clumps, which scientists believe could stop PD in its tracks.
  • Several potentially disease-modifying therapies continue to advance via “repurposing” — scientifically evaluating drugs approved for various conditions for their benefit in PD. Isradipine (a hypertension drug) and inosine (an antioxidant supplement) are now in Phase III trials. The field also has seen promise in the diabetes drug exenatide and the cancer drug nilotinib.

New meds, in trial

 

Ketosis and Ketosis Supplements

  •  high-fat, low-carb keto diet. Being in ketosis, the state where your body uses fat instead of glucose for energy, increases the NAD+ to NADH ratio. You want higher NAD+, because it protects cells from oxidative stress[20][21] — an imbalance between free radicals and antioxidants in your body that contributes to aging.[22][23]
  • Practice intermittent fasting. Restricting your eating increases NAD+ levels.[24][25] Though calorie-restriction diets and periods of fasting will do it, those aren’t sustainable for the long term. Intermittent fasting is, if you do it right. Here’s how to get started with intermittent fasting.
  • Take oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate.

NADD+ and NADH

NADH for PD:

(NADH) has been used as medication in 885 PD patients in an open label trial. About half of the patients received NADH by intravenous infusion, the other part orally by capsules. In about 80% of the patients a beneficial clinical effect was observed

NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344

older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf

NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh

NR+?

Most sources say boost  NAD+ using precursors or NAD+ supplement (NMN, NR)

also oxaloacetate :

oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate

see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x

NAD+

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

NADH for PD:

short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…

liposomal NMN ?

all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)

Metformin 1 gr at night (checkout supplement alternative Berberine )

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily

make a list according to this guy

checkout Uleic vs resveratrol

Risk:

Metformin may increase risk of PD and other neurodegenerative disease

Keto for PD, Some Evidence

…What are the benefits of Ketosis?
Achieving a state of ketosis can have many benefits from treating chronic illnesses to optimizing performance. While the benefits are well documented, the underlying mechanism of action is not entirely known. The diet seems to enhance the ability of mitochondria, the power plants of our cells, to deliver our bodies’ energy needs in a manner that reduces inflammation and oxidative stress. Through optimizing the way our body uses energy, we fortify our bodies’ ability to take on the ever-growing stressors of our modern way of living.

some results:
charliefoundation.org/keto-for-parkinsons/

Vitamin D

does vit D cause calcification of arteries?
according to one article, it could in some settings, not clear when, many other sources point out the benefits of vit d

Vitamin D in Vascular Calcification: A Double-Edged Sword?

#q
How much sun exposure is needed for vit D instead of supplements?

answer from https://www.healthline.com/nutrition/vitamin-d-from-sun#time-of-day

At noon, the sun is at its highest point, and its UVB rays are most intense. That means you need less time in the sun to make sufficient vitamin D (5Trusted Source).

Many studies also show that the body is most efficient at making vitamin D at noon (6Trusted Source, 7Trusted Source).

For example, in the UK, 13 minutes of midday sunlight exposure during summer three times per week is enough to maintain healthy levels among Caucasian adults (5Trusted Source).

Another study found that 30 minutes ttof midday summer sun exposure in Oslo, Norway was equivalent to consuming 10,000–20,000 IU of vitamin D (8Trusted Source).

The commonly recommended daily dose of vitamin D is 600 IU (15 mcg) (3).

Vitamin D is critical for brain health…