P0 Archives - Page 3 of 3 -

Probiotics for constipation

yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019
The product containing yogurt with polydextrose, B. lactis HN019 and L. acidophilus NCFM® significantly shortened colonic transit time after two weeks

Meta analysis: Bifidobacterium lactis works best, Lactobacillus casei Shirota not so good

New treatments for PD, in trials

direct administration to the brain (that’s new) of GDNF (also new)

The FDA granted approval of Nourianz to Kyowa Kirin, Inc.

A universal feature of Parkinson’s is aggregation, or clumping, of the protein alpha-synuclein in the brains and body cells of people with the disease (similar to the amyloid clumps seen in Alzheimer’s disease). Multiple drug companies are conducting clinical trials to try to prevent or break up synuclein clumps, which scientists believe could stop PD in its tracks.
Several potentially disease-modifying therapies continue to advance via “repurposing” — scientifically evaluating drugs approved for various conditions for their benefit in PD. Isradipine (a hypertension drug) and inosine (an antioxidant supplement) are now in Phase III trials. The field also has seen promise in the diabetes drug exenatide and the cancer drug nilotinib.

New meds, in trial

Sulforaphane, boost liver enzyme, Broccoli sprouts

www.ncbi.nlm.nih.gov/pmc/articles/PMC4649129/

Dr Ronda Patrick

NADD+ and NADH

NADH for PD:

(NADH) has been used as medication in 885 PD patients in an open label trial. About half of the patients received NADH by intravenous infusion, the other part orally by capsules. In about 80% of the patients a beneficial clinical effect was observed

NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344

older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf

NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh

NR+?

Most sources say boost NAD+ using precursors or NAD+ supplement (NMN, NR)

also oxaloacetate :

oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,^[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate

NAD+

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

NADH for PD:

Nicotinamide adenine dinucleotide (NADH)–a new therapeutic approach to Parkinson’s disease. Comparison of oral and parenteral application.

short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…

liposomal NMN ?

all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)

Metformin 1 gr at night (checkout supplement alternative Berberine )

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily