early puberty & EDC – endocrine disraptors

MedicalMedia.co.il דף ראשי: שער הכניסה של הרופאים לאינטרנט, חיפוש מידע רופאי מושכל, חיפוש תרופות מושכל, כתבי עת רפואיים, כינוסים, ספרייה רפואית וכל המידע שלו זקוק הרופא נמצא ב MedicalMedia

Source: Israeli Journal of Pediatrics – התבגרות מינית: מה התחדש בעשורים האחרונים?

Metallothionein

www.walshinstitute.org/uploads/1/7/9/9/17997321/metallothionein-pp.pdf

Recommended MT-Promotion Formulation

Glutathione 200.0 mg
Alanine 16.8 mg
Asparagine 5.5 mg
Aspartic Acid 8.5 mg
Glutamic Acid 12.0 mg
Glutamine 4.4 mg
Glycine 11.6 mg
Isoleucine 4.0 mg
Lysine 35.7 mg
Methionine 6.3 mg
Proline 7.0 mg
Serine 27.4 mg
Threonine 8.6 mg
Valine 2.2 mg
Selenium** 200.0 mcg (as selenomethionine)

book: www.amazon.com/Nutrient-Power-Heal-Biochemistry-Brain-ebook/dp/B00J75IQUA

Magnesium to prevent and reverse Aurtic stenosis and calcification in general

the SEM data show that the protein-protein cross-linking bonds are the starting sites of calcification. In addition, substitution of Ca2+ cations by Mg2+ cations leads to the formation of amorphous hydroxyapatite, preventing aortic valve stenosis, which suggests that treatment with magnesium salts may reduce stenosis of aortic valves…
iv.iiarjournals.org/content/28/1/91.full

We observed strong, favorable associations between higher self-reported total (dietary and supplemental) magnesium intake and lower calcification of the coronary arteries…
www.ncbi.nlm.nih.gov/pmc/articles/PMC3957229/

Studies showed that a calcium to magnesium intake ratio <2.8 is critical for optimal health, supporting a long-held but non–evidence-based recommendation that the calcium to magnesium ratio should be close to 2. Increasing calcium intakes in the United States since 1977 have resulted in a calcium to magnesium ratio >3.0 since 2000, coinciding with increasing rates of T2D and colorectal cancer. US studies assessing oral magnesium therapy or dietary magnesium intakes showed beneficial effects of dietary magnesium in CVD, T2D, and cancers, although similar studies in populations with lower calcium to magnesium ratios (≥1.7) reported the opposite…
www.ncbi.nlm.nih.gov/pmc/articles/PMC4717874/

 

Ketosis and Ketosis Supplements

  •  high-fat, low-carb keto diet. Being in ketosis, the state where your body uses fat instead of glucose for energy, increases the NAD+ to NADH ratio. You want higher NAD+, because it protects cells from oxidative stress[20][21] — an imbalance between free radicals and antioxidants in your body that contributes to aging.[22][23]
  • Practice intermittent fasting. Restricting your eating increases NAD+ levels.[24][25] Though calorie-restriction diets and periods of fasting will do it, those aren’t sustainable for the long term. Intermittent fasting is, if you do it right. Here’s how to get started with intermittent fasting.
  • Take oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate.

NADD+ and NADH

NADH for PD:

(NADH) has been used as medication in 885 PD patients in an open label trial. About half of the patients received NADH by intravenous infusion, the other part orally by capsules. In about 80% of the patients a beneficial clinical effect was observed

NADH for brain issues
www.ncbi.nlm.nih.gov/pubmed/29634344

older research
pdfs.semanticscholar.org/ed59/9c8a4b6e45592c8da1099103c5797e82f87b.pdf

NAD+ vs NADH
www.elysiumhealth.com/en-us/knowledge/science-101/whats-the-difference-between-nad-and-nadh

NR+?

Most sources say boost  NAD+ using precursors or NAD+ supplement (NMN, NR)

also oxaloacetate :

oxaloacetate. A higher ratio of NAD+ to NADH helps you make more energy and makes your cells work better. Oxaloacetate activates the longevity pathway in a similar way that calorie restriction does. It converts to malate, which raises your NAD+ to NADH ratio,[26] which makes more NAD+ available for your cells to use. Try: KetoPrime, a highly bioavailable form of oxaloacetate

see also https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00527.x

NAD+

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

NADH for PD:

short history of NAD related work from 2016, anecdotal evidence suggest its a game changer
measuring NAD is hard to do
precursors taken orally – do they surviv? NADD patched, iv,supossitory…

liposomal NMN ?

all precursors will be tested soon
NAD deficit might be high so that 2x increase in NAD level is not significant

David Sinclair personal anti aging supplements protocol

NMN 1 gr with food(fat) in the morning, proven to raise NAD

Reversatol 0.5 gr (checkout Uleic acid – olive oil alternative)

Metformin 1 gr at night (checkout supplement alternative Berberine )

#q1: checkout this supplement
il.iherb.com/pr/Thorne-Research-ResveraCel-60-Capsules/69377

#q2: interaction with Warfarin

Avoid mamals due to TAMO
From 4:30 here:

another list,from fastlifehacks.com/david-sinclair-supplements/

David Sinclair Takes:

Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
Aspirin – 83mg daily

make a list according to this guy

checkout Uleic vs resveratrol

Risk:

Metformin may increase risk of PD and other neurodegenerative disease

Fetal tissue implant – Wikipedia

Source: Fetal tissue implant – Wikipedia

…In 1982, seven people in Santa Clara County, California were diagnosed with Parkinsonism after having used MPPP contaminated with MPTP. In 1992, two of the seven patients were successfully treated at Lund University Hospital in Sweden with neural grafts of fetal tissue. One patient, who had been essentially paralyzed, regained enough motor function to ride a bicycle.[1]

נזקי כספית, אמלגם

ש לציין שהחריגות הגבוהות ביותר נמדדו בקידוח סתימות ישנות. יתרה מכן, בשנת 2002 פורסמה עבודה שבדקה 180 רופאי שיניים, ומצאה רמות כספית שעולה על הרמה המומלצת ע”י ה – Health and Safety Executive’s. חוקרים נוספים ערכו ניסוי קליני ובמהלכו הוסרו והוחלפו 50 סתימות אמלגם ישנות ותוך כדי כך נעשו מדידות של רמות אדי כספית באזור דרכי נשימה של רופאי שיניים. בחלק מהפעולות נמדדו רמות אדי כספית גבוהות מה TLV בין פי 2 עד פי 15

 

ארגון הבריאות העולמי וה 

FDA 

על אמלגם

 

High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson’s Disease – IOS Press

Background: Reduced glucose tolerance has been long recognized as a potential risk factor for Parkinson’s disease (PD), and increasing scrutiny is currently being placed on insulin resistance (IR) as a pathologic driver of neurodegeneration. However,

Source: High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson’s Disease – IOS Press

for comparison, prevalence of Diabetes in the general population:

Depending on age groups, global diabetes prevalence is about 5% for the age group 35-39 years, 10% for the age group 45-49 years, 15% for the age group 55-59 years, and close to 20% starting at age group 65-69 years. (1) Diabetes prevalence numbers are largely determined by people with type2 diabetes who comprise about 90% of the total population. These individuals are characterized by various degrees of relative insulin deficiency in conjunction with a wide spectrum of insulin resistance

its high – 20% suggesting much higher prevalence of IR, not sure if IR in PD is that much above normal